) 1认知与人格教育部重点实验室
2西南大学心理学部, 重庆 400715
收稿日期:2020-08-07出版日期:2021-06-15发布日期:2021-04-25通讯作者:陈伟海E-mail:whchen@swu.edu.cn基金资助:中央高校基本科研业务费专项资金资助(SWU1709247)Mechanisms underlying the role of D2 receptors in regulating sensory gating
OU Huaxing1,2, CHEN Weihai1,2() 1Key Laboratory of Cognition and Personality (SWU), Ministry of Education
2Faculty of Psychology, Southwest University, Chongqing 400715, China
Received:2020-08-07Online:2021-06-15Published:2021-04-25Contact:CHEN Weihai E-mail:whchen@swu.edu.cn摘要/Abstract
摘要： 精神分裂症是一种常见的病因不明的精神疾病。大量文献表明精神分裂症患者所表现出来的认知紊乱和思维异常等症状与感觉门控功能的缺失有密切的关系, 感觉门控是指在充满刺激的环境中, 从外界的感觉信息中过滤无关的感觉信息然后执行与注意力相关的认知过程, 以对显著的刺激做出反应。研究感觉门控的经典范式是震惊反射的前脉冲抑制。研究发现多巴胺D2受体可以参与调控前脉冲抑制的过程, 但是多巴胺D2受体参与调控前脉冲抑制的机制仍不清楚。探讨多巴胺D2受体参与调控感觉门控即前脉冲抑制的关键脑区、神经环路及分子机制, 有利于促进对精神分裂症感觉门控功能的深入研究。
图/表 2
图1前脉冲抑制的初级环路。听觉传入到下丘, 上丘接收到下丘声音刺激的传入并将其传递到脑桥脚被盖核, 脑桥脚被盖核发出神经纤维, 投射到震惊反射中枢的尾侧脑桥网状核并发挥对震惊反射抑制性的调节作用。
图1前脉冲抑制的初级环路。听觉传入到下丘, 上丘接收到下丘声音刺激的传入并将其传递到脑桥脚被盖核, 脑桥脚被盖核发出神经纤维, 投射到震惊反射中枢的尾侧脑桥网状核并发挥对震惊反射抑制性的调节作用。
图2中脑边缘皮质-纹状体-腹侧苍白球-脑桥回路(CSPP)回路。腹侧被盖区向边缘皮质(前额叶、杏仁核、海马)发出多巴胺能神经纤维, 而纹状体接受来自边缘皮质的谷氨酸能神经投射和腹侧被盖区的多巴胺能神经投射, 并发出GABA能神经投射到腹侧苍白球、脑桥脚被盖核以及腹侧被盖区, 从而实现对PPI的调控。
图2中脑边缘皮质-纹状体-腹侧苍白球-脑桥回路(CSPP)回路。腹侧被盖区向边缘皮质(前额叶、杏仁核、海马)发出多巴胺能神经纤维, 而纹状体接受来自边缘皮质的谷氨酸能神经投射和腹侧被盖区的多巴胺能神经投射, 并发出GABA能神经投射到腹侧苍白球、脑桥脚被盖核以及腹侧被盖区, 从而实现对PPI的调控。参考文献 80
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