Progress on biosynthesis and function of the natural products of Zi Cao as a traditional Chinese medicinal herb
Hongyan Lin, Xuan Wang, Cong He, Ziling Zhou, Minkai Yang, Zhongling Wen, Hongwei Han, Guihua Lu, Jinliang Qi, Yonghua Yang,State Key Laboratory of Pharmaceutical Biotechnology, Institute for Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, China
Supported by the National Natural Science Foundation of China Nos.U1903201 Supported by the National Natural Science Foundation of China Nos.31670298 Supported by the National Natural Science Foundation of China Nos.31771413 Supported by the National Natural Science Foundation of China Nos.21702100 Supported by the National Natural Science Foundation of China Nos.21907051 the Program for Changjiang Scholars and Innovative Research Team in University from the Ministry of Education of China No.IRT_14R27
作者简介 About authors 林红燕,博士,助理研究员,研究方向:药用植物天然产物化学和分子药理。E-mail:linhy@nju.edu.cn。
Abstract Zi Cao is an important traditional medicinal plant resource in China. Shikonin and its derivatives, as the purple-red naphthoquinones among natural products of its roots, are commonly used clinically in the treatment of sores and skin inflammations. Over the past few decades, due to their highly effective multiple biological activities, pharmacological effects, good clinical efficacy and high utilization value, shikonin and its derivatives have attracted increasing attention of domestic and foreign researchers. For this reason, the wild plant germplasm resources have been suffering a grievous exploitation, leading to a serious threat to the habitat. With the development of the biosynthesis, molecular metabolism and biotechnology, as well as the continuous innovation of research methods on the biological activities and pharmacological effects of plant natural products, significant progress has been made in the research on the biosynthetic pathways and related regulatory genes of shikonin. The pharmacological action and its mechanism of shikonin have also been deeply elucidated, which greatly promoted the basic research and clinical application development of shikonin. In this review, we briefly introduce and analyze the classification of Zi Cao, structure and composition of natural shikonin and its biosynthesis pathway, functional genes related to the regulation of shikonin biosynthesis, and biological activities and pharmacological functions of shikonin. Finally, we address possible prospective for the trend on the future research and development of natural shikonin and its derivatives, hoping to provide a useful reference for the deep mining and development of medicinal natural products from important Chinese medicinal materials, and to promote the modern development of traditional Chinese medicine. Keywords:Zi Cao;shikonin;biosynthesis;gene regulation;pharmacological activity
PDF (914KB)元数据多维度评价相关文章导出EndNote|Ris|Bibtex收藏本文 本文引用格式 林红燕, 王煊, 何聪, 周紫玲, 杨旻恺, 文钟灵, 韩洪苇, 陆桂华, 戚金亮, 杨永华. 中药植物紫草天然产物的生物合成及其功能研究进展. 遗传[J], 2021, 43(5): 459-472 doi:10.16288/j.yczz.20-341 Hongyan Lin. Progress on biosynthesis and function of the natural products of Zi Cao as a traditional Chinese medicinal herb. Hereditas(Beijing)[J], 2021, 43(5): 459-472 doi:10.16288/j.yczz.20-341
根据参考文献[9]修改绘制。A:紫草宁类;B:阿卡宁类。R为取代基团;1:紫草素;2:去氧紫草素;3:乙酰紫草素;4:ɑ-甲基-正丁酰紫草素;5:异丁酰紫草素;6:异戊酰紫草素;7:β-羟基异戊酰紫草素;8:β,βʹ-二甲基丙烯酰紫草素;此外,4与6又属于同分异构体。 Fig. 1Natural shikonins of Zi Cao
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