摘要/Abstract
摘要： 目的 ·评价子宫内膜异位症患者生存质量量表 (endometriosis health profile-5, EHP-5)中文版的信度和效度以及对于不同症状患者的适用程度。方法 ·制作中文版 EHP-5，并对 102例子宫内膜异位症患者进行问卷调查，运用 R软件进行信度及效度检验。效标效度分析以欧洲五维健康量表 (EuroQol five-dimension questionnaire，EQ-5D)作为有效标准。另外分别按照痛经、性交痛、月经失调及不孕症状将患者进一步分组，对各组患者所填写的核心问卷各条目得分进行 Mann-Whitney U检验。结果 · EHP-5 中文版核心问卷和模块问卷的信度系数分别为 0.877与 0.843，内部一致性系数（ Cronbachs α）均大于 0.7。EHP-5与 EQ-5D各条目间的相关系数在多个维度比较下差异具有统计学意义。按症状分类后，在有无痛经及有无性交痛的患者中，核心问卷各条目得分的差异均有统计学意义；而在有无月经失调及不孕和已孕的患者中，核心问卷部分条目得分的差异无统计学意义。结论 ·中文版 EHP-5具有较好的信度及效度，其在对具有痛经或性交痛的子宫内膜异位症患者的生活质量评估时敏感度高，但其对不孕或月经失调患者的敏感度较低。故还需设计对症状更具针对性的条目，用以作为适用于不同症状患者预后及随访的干预研究工具。
关键词: 子宫内膜异位症, 子宫内膜异位症患者生存质量量表（ EHP-5）, 信度, 效标效度
Abstract:
Objective · To evaluate the reliability and validity of the Chinese version of the endometriosis health profile-5 (EHP-5) and to evaluate whether patients with different syndromes can be well discriminated with EHP-5. Methods · A total of 102 patients with pathologically proven endometriosis completed the questionnaire. The reliability and internal consistency of the Chinese version of EHP-5 were assessedCronbachs α coefficient. Creteria validity of the Chinese version of EHP-5 was investigatedcomparing it with the EuroQol five-dimension questionnaire (EQ-5D). The patients were further subdivided into two subgroups according to the symptom of dysmenorrhea, dysmenorrhea, menstrual disorder or infertility. The scores in the five items of core questionnaire were compared between asymptomatic and symptomatic patients using Mann-Whitney U test. Results · The Cronbachs α coefficient was 0.877 for five items the core questionnaire, and 0.843 for six items the modular questionnaire. The internal consistency also showed satisfactory result (Cronbachs α >0.7). The correlations of related subscale scores between EHP-5 and EQ-5D were significant in some dimensions. There was significant differences in scores between asymptomatic and symptomatic subgroups dividedthe symptom of dysmenorrhea or dyspareunia. But no significant difference was founds in scores between asymptomatic and symptomatic subgroups dividedthe symptom of menstrual disorders or infertility. Conclusion · The Chinese version of EHP-5 is an acceptable, reliable and valid measure of quality of life in endometriosis patients with the symptom of dysmenorrhea or dysmenorrhea. However, EHP-5 could not well discriminate endometriosis patients with the symptom of menstrual disorder or infertility. More specific items are necessary so as to make EHP-5 an intervention tool for the prognosis and follow-up of patients with different symptoms.
Key words: endometriosis, endometriosis health profile-5 (EHP-5), reliability, creteria validity
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