摘要/Abstract

摘要： 目的 ·探讨乳腺癌患者不同化学治疗（化疗）阶段体质量和体力活动状况及对化疗后生活质量的影响。方法 ·采用方便抽样法，选取首次接受辅助化疗的乳腺癌患者，在化疗前、中、后进行 3次纵向跟踪人体学测量，采用国际体力活动评价量表和乳腺癌患者生命质量测定量表（中文版）进行问卷调查，对所得数据进行重复测量方差分析和相关性分析。结果 · 140例乳腺癌患者化疗期间肥胖患者平均占比达 30.24%。伴随着化疗进展，患者体质量指数有显著增加趋势；化疗期间患者体力活动中位数 844.50（MET · min）/周；化疗前肥胖患者与其化疗末期生活质量总分呈负相关（ r-0.21，P0.014），而其体力活动能量消耗与生活质量总分呈正相关（ r0.20， P0.019）。结论 ·化疗期乳腺癌患者中肥胖和缺乏体力活动现象较为多见，且两者与患者化疗后生活质量密切相关。
关键词: 乳腺癌, 肥胖, 体力活动, 化学治疗, 生活质量
Abstract:
Objective · To investigate the impact of body weight and physical activity during different stages of adjuvant chemotherapy on the quality of life after chemotherapy among breast cancer patients. Methods · In a convenient sample of breast cancer patients with no prior history of systemic therapy, physical activity and quality of life were measured with anthropometric measurements, international physical activity evaluation questionnaire and Chinese version of functional assessment of cancer therapy-breast (FACT-B) scale before, during and after chemotherapy. Data was processed using repetitive measurement variance analysis and correlation analysis. Results · Among the 140 breast cancer patients, the average incidence of obesity during chemotherapy was 30.24%. An increase of body mass index (BMI) was observed throughout the treatment course. During adjuvant chemotherapy, the median physical activity was 844.50 (MET·min)/week. Obesity before chemotherapy was significantly negatively correlated with quality of life among patients receiving adjuvant chemotherapy (r-0.21, P0.014), while physical activity energy consumption was positively correlated with quality of life (r0.20, P0.019). Conclusion · Obesity and insufficient physical activity are rather common during adjuvant chemotherapy treatment in breast cancer patients, and they are strongly correlated with patients quality of life after chemotherapy.
Key words: breast cancer, obesity, physical activity, chemotherapy, quality of life


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