摘要/Abstract
三芳基甲烷及其衍生物在纺织、医药等领域被广泛应用, 有关它的高效合成方法备受研究者的关注. 本研究选用了绿色的深共融溶剂[ChCl][ZnCl2]协同促进苯甲醛与N-取代苯胺之间的Baeyer缩合反应, 高效地合成了多种三芳基甲烷衍生物. 该方法采用了深共融溶剂作为催化剂和绿色反应介质, 无需额外添加催化剂, 仅用几个小时就能得到目标产物. 此外, 深共融溶剂在此过程中重复使用了多次, 且没有明显的活性损失.
关键词: 三芳基甲烷衍生物, 深共融溶剂, Baeyer缩合, 绿色化学
Triarylmethane derivatives and their syntheses are of great interest owing to their broad applicability in areas from textiles to medicine. In this study, the green solvent [ChCl][ZnCl2] synergistically promoted Baeyer condensation between benzaldehyde and N-substituted aniline to efficiently synthesize triarylmethane derivatives with high para-selectivity. The employed deep eutectic solvent acted as both a catalyst and green reaction medium for the reaction. Moreover, the deep eutectic solvent was reused several times in this procedure without significant loss of activity.
Key words: triarylmethane derivatives, deep eutectic solvents, Baeyer condensation, green chemistry
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