摘要/Abstract

过渡金属催化的C(sp²)—C(sp³)交叉偶联在有机合成中具有重要意义, 可用于合成复杂天然产物和药物分子. 近年来, 还原Heck反应已发展成为构筑C(sp²)—C(sp³)键的简洁、高效方法之一. 根据参与反应的氢供体类型不同, 综述了近十年来烯烃参与还原Heck反应的研究进展. 对其作用机理进行了阐述, 并对该领域的未来发展进行了展望.
关键词: 烯烃, 过渡金属催化, 还原Heck反应, C(sp²)—C(sp³)键构建
Transition-metal catalyzed C(sp²)—C(sp³) cross-coupling is of great significance in organic chemistry for synthesizing complex natural products and pharmaceutical molecules. Recently, reductive Heck reactions have emerged as one of the simple and efficient strategies for the construction of C(sp²)—C(sp³) bond. The recent advances in the reductive Heck reactions of alkenes are summarized on the basis of different hydride sources. The related mechanisms are provided, and the future development of this field is also prospected.
Key words: alkene, transition-metal catalysis, reductive Heck reaction, C(sp²)—C(sp³) formation


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