摘要/Abstract
报道了金属引导由N-(2-炔基芳基)内酰胺发散型合成羰基稠合的吲哚/吡咯的方法. 该反应通过可调控的酰基正离子区域选择性傅-克环化反应进行, 同时具有底物范围广, 原子经济性和步骤经济性高等优势, 有望用于含有相关结构的生物活性分子的合成.
关键词: 傅-克环化反应, 羰基稠合的吲哚/吡咯, 发散型合成
A metal-guided method for divergent synthesis of ketone-fused indoles/pyrroles from N-(2-alkynylaryl) lactam is described. The reaction is proposed to proceed through a regioswitchable Friedel-Crafts cyclization of acylium. The obvious advantages are wide substrate scopes, high atom economy and step economy, which have a great potential in the synthesis of structure-related bioactive compounds.
Key words: Friedel-Crafts cyclization, ketone-fused indoles/pyrroles, divergent synthesis
PDF全文下载地址:
点我下载PDF
