摘要/Abstract

烯醇类化合物氧化偶联反应作为直接构建C—C键的高效合成方法之一, 是有机化学领域研究关注的重点. 尽管首例烯醇类化合物氧化偶联反应早在1935年就已被报道, 但直到20世纪70年代才得到化学家们的广泛重视, 不过当时反应的有效性和实用性仍有待进一步提高. 近年来, 该反应在有机合成方法学和天然产物全合成方面都取得了快速的发展. 因此, 重点概述了近十年来该类型反应合成方法学的发展及其在天然产物全合成的应用研究进展.
关键词: 氧化偶联反应, 烯醇类化合物, 碳碳键, 方法学, 天然产物
Oxidative coupling reaction of enol derivatives (enolates, enol silanes, enamines, etc.) provides an efficient method for the direct construction of carbon-carbon bond, which plays a prominent role in the field of synthetic chemistry. Although the first case of this reaction had been reported in 1935, it was not until the 1970s that chemists began to pay more attention to this reaction. However, the effectiveness and practicability of this reaction were still somewhat limited at that time. In recent years, this reaction has been developed rapidly in the field of synthetic methodology and the total synthesis of natural products. Therefore, these advances in methodologies and its applications in the total synthesis of natural products in the last decades are mainly summarized.
Key words: oxidative coupling reaction, enol derivatives, carbon-carbon bond, methodology, natural product


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