摘要/Abstract
开发了一种以芳基甲基酮或脂肪酮和2-氨基苯硫酚为原料, 正丁醇为溶剂, 120 ℃条件下经Selectfluor氧化合成2-取代苯并噻唑类衍生物的方法. 通过改变底物芳基甲基酮上的取代基可以获得具有生物活性的药物中间体.
关键词: 选择性氟试剂, 2-芳基苯并噻唑, 芳基甲基酮, 2-氨基苯硫酚, 氧化
2-Arylbenzothiazoles were effectively synthesized via an oxidative process by Selectfluor in 1-butanol at 120 ℃, using 2-arylbenzothiazoles and aryl/aliphatic ketones as starting materials. Bioactive pharmaceutical intermediates were obtained by selecting substituents on the ring of aryl methyl ketones.
Key words: Selectfluor, 2-arylbenzothiazole, aryl methyl ketone, 2-aminobenzenethiol, oxidation
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