摘要/Abstract

发展了一种非金属催化下高效构筑多取代苯的新方法. 以10 mol%的Cs₂CO₃为催化剂, 一系列α-氰基-β-甲基烯基(杂)芳基酮可在极其温和的反应条件下与丁炔二酸酯发生[4+2]环加成/脱水芳构化苯增环反应, 以62%~94%的收率生成1,2-二酯基-3-(杂)芳基-4-氰基苯衍生物.
关键词: α-氰基-β-甲基烯基(杂)芳基酮, 丁炔二酸酯, [4+2]环加成反应, 1,2-二酯基-3-(杂)芳基-4-氰基苯衍生物
A mild and transition-metal free method for rapid construction of benzene frameworks has been developed. Under the catalysis of 10 mol% Cs₂CO₃, a variety of α-cyano-β-methylalkenyl(hetero)aryl ketones undergo [4+2] annulation with different dialkyl butynedioates efficiently to produce 1,2-diesteryl-3-(hetero)aryl-4-cyanobenzene derivatives in 62%~94% yields.
Key words: α-cyano-β-methylalkenyl(hetero)aryl ketones, dialkyl butynedioates, [4+2] annulation, 1,2-diesteryl-3-(hetero)- aryl-4-cyanobenzene derivatives


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