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三氟甲基季碳中心的合成进展

本站小编 Free考研考试/2022-02-14

摘要/Abstract



三氟甲基是一个重要的含氟基团,常被应用于药物和农药领域.季碳中心是广泛存在于天然产物和合成药物中的结构.近年来,构建含有三氟甲基季碳中心的分子得到了快速发展.从直接三氟甲基化反应、新的合成砌块和新反应的探索几个方面,综述了近十年来合成三氟甲基季碳中心的研究进展.
关键词: 三氟甲基, 季碳中心, 合成进展
Trifluoromethyl is an important group, which is often used in pharmecuticals and agrochemicals. Quaternary carbon centers are widely existed in natural products and synthetic compounds. Recently, the construction of molecules containing trifluoromethylated quaternary carbon centers has been developed rapidly. Starting with direct trifluoromethylation, new synthons and new reactions, the research progress of the synthesis of trifluoromethylated quaternary carbon centers is reviewed.
Key words: trifluoromethyl, quaternary carbon center, research progress


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