摘要/Abstract

异噁唑衍生物由于其良好的生物活性一直受到有机合成化学家的关注，例如异噁唑衍生物具有杀虫、杀菌等生物活性.以3-芳基4-异噁唑甲酸乙酯为原料，经还原、溴化、取代反应合成了一系列3-芳基-4-芳胺甲基异噁唑衍生物，目标化合物结构经过¹H NMR、¹³C NMR、HRMS鉴定.初步的生物活性测试结果显示，部分化合物对蚜虫和粘虫具有较好的抑制率.
关键词: 异噁唑衍生物, 合成, 芳胺甲基, 生物活性
The synthesis of isoxazole derivatives has been paid much attention by organic synthetic chemists because isoxazoles usually exhibit good biological activity such as insecticidal and bactericidal activity. In this study, a series of 3-aryl-4-arylamine methyl isoxazole derivatives were synthesized from ethyl 3-arylisoxazole-4-carboxylate by reduction, bromination and substitution reaction. The synthesized compounds were identified by ¹H NMR, ¹³C NMR and HRMS, and the preliminary bioactivity test results showed that some compounds obtained had good inhibitory effects anainst aphids and armyworms.
Key words: isoxazole derivative, synthesis, arylamine methyl group, biological activity


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