摘要/Abstract

为了探索新的吡唑酰胺活性物质，基于吡螨胺的结构，将噻唑环通过酰胺键同吡唑环相连，合成了18个未见文献报道的吡唑酰胺类化合物，通过¹H NMR，¹³C NMR和元素分析等手段确证了其结构.生物活性测试研究显示，所有目标化合物在500 μg/mL时对粘虫都有100%的杀虫活性.7个目标化合物在500 μg/mL时对蚜虫具有70%~100%的防治效果.同时，3个目标化合物在500 μg/mL时对朱砂叶螨显示出40%~50%的防效.
关键词: 噻唑, 吡唑酰胺, 合成, 杀虫活性
In search of novel pyrazole amide compounds possessing good biological activities, a series of pyrazole amides were synthesized by introducing thiazole unit into pyrazole ring via amido bond, based on the lead of tebufenpyrad. The title compounds were structurually confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay displayed that all the title compounds exhibited 100% insecticidal activities against Oriental armyworm at 500 μg/mL. At the concentration of 500 μg/mL, seven compounds showed 70%~100% mortality rate against Aphis medicaginis. In addition, three compounds had 40%~50% insecticidal activity against Tetranychus cinnabarinus at 500 μg/mL.
Key words: thiazole, pyrazole amide, synthesis, insecticidal activity


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