摘要/Abstract

以7-羟基四氢喹喔啉-6-甲醛为基础，设计合成了一种新型酰腙类荧光探针L，探针在DMSO/Tris（V：V=7：3）溶液中能够高选择性识别Al³⁺.向该探针中加入Al³⁺后由无荧光变为紫红色荧光，最大发射波长为640 nm，达到近红外范围，并且具有较大的斯托克斯位移（170 nm），检测限为0.521 μmol/L，pH适用范围为5～9.此外，探针L可在实际水样中对Al³⁺进行检测，还可在MCF-7细胞中对Al³⁺进行荧光成像.
关键词: 7-羟基四氢喹喔啉-6-甲醛, 荧光探针, Al³⁺, 识别, 细胞成像
A novel acylhydrazone derivative (i.e. fluorescence probe L) was designed and synthesized based on 7-hydroxy- tetrahydroquinoxaline-6-formaldehyde. Probe L can recognize for Al³⁺ with highly selectivity in DMSO/Tris (V:V=7:3) solution. When Al³⁺ is added into the solution of L, the fluorescence color of solution changes from non-fluorescence to purple red fluorescence, and the maximum emission wavelength of L is 640 nm within range of the near-infrared. Probe L possesses a large Stokes shift (170 nm) and the detection limit of L is 0.521 μmol/L. In addition, L can detect Al³⁺ in the real water samples and imaging for Al³⁺ in MCF-7 cells.
Key words: 7-hydroxytetrahydroquinoxaline-6-formaldehyde, fluorescent probe, Al³⁺, recognition, cell imaging


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