摘要/Abstract

为了寻找具有良好生物活性的吡唑酰胺化合物，基于氯虫苯甲酰胺的结构，在吡唑环的5-位引入取代噁唑环单元，合成出了一系列新型吡唑酰胺，利用¹H NMR，¹³C NMR和元素分析对其目标产物的结构进行了确证.生测结果表明，所有目标化合物在500 μg/mL时对粘虫均显示出较好的杀虫活性（致死率≥ 90%）.5个化合物在100 μg/mL时对粘虫的防治效果可达90%~100%，3个化合物在100 μg/mL时对苜蓿蚜的杀死率为90%~100%.另外，2个化合物在500 μg/mL时对朱砂叶螨的防效可达80%~100%.
关键词: 噁唑, 吡唑酰胺, 合成, 生物活性
In order to find new pyrazole amides with wonderful bioactivities, a series of novel pyrazole amide derivatives were synthesized by introducing substituted oxazole ring into the C-5 position of pyrazole skeleton based on the lead chlorantraniliprole. The aimed compounds were structurally characterized through ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassay results exhibited that all the title compounds displayed more than 90% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL. At the dosage of 100 μg/mL, five compounds possessed 90%~100% insecticidal activities against Mythimna separata (Walker), and three compounds exhibited insecticidal property against Aphis craccivora with 90%~100%. Additionally, at the dosage of 500 μg/mL, two compounds possessed insecticidal activity against Tetranychus cinnabarinus with 80%~100%.
Key words: oxazole, pyrazole amide, synthesis, bioactivity


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