摘要/Abstract

基于水相条件下发展了一种绿色高效的吡唑啉酮与三氟甲基酮的亲核加成的方法，且以高收率获得吡唑啉酮取代的叔三氟甲基醇类化合物.该方法具有的无催化剂、无色谱柱分离、环境友好以及易于后处理的优点使其在制备各种吡唑啉酮取代的叔三氟甲基醇类化合物中很有应用前景.
关键词: “水上”反应, 亲核加成, 吡唑啉酮, 三氟甲基酮
A green and efficient nucleophilic addition reaction of trifluoromethyl ketone with pyrazolone was developed under "on water" conditions, affording pyrazolone substituted tertiary trifluoromethyl alcohols in high yields. The advantages of being catalyst-free, column chromatography-free, environmentally benign and easy workup make it a promising method for preparation of a variety of pyrazolone substituted tertiary trifluoromethyl alcohols.
Key words: “on water” reaction, nucleophilic addition, pyrazolone, trifluoromethyl ketone


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