摘要/Abstract

报道了一种高效合成1，3，4-噻二嗪类化合物的新方法.以含不同取代基的α-氯代腙和2，5-二羟基-1，4-二噻烷为原料，合成了13个化合物，除（E）-4-苯基-2-苯乙烯-5，6-二氢-4H-1，3，4-噻二嗪-5-醇（3m）外，其余化合物收率均在82%以上.此外，对反应可能的机理进行了探讨.该方法操作简单，反应条件温和，对环境友好，产率高，并且底物普适性好，为1，3，4-噻二嗪类化合物的合成提供了一种新途径.
关键词: α-氯代腙, 1,3,4-噻二嗪, 合成
An efficient method for the preparation of 1,3,4-thiadiazine derivatives has been reported. With 2,5-dihydroxy-1,4-dithiane and α-chloroindole containing different substituents, 13 compounds were synthesized. The yields of the compounds were above 82% except (E)-4-phenyl-2-styryl-5,6-dihydro-4H-1,3,4-thiadiazin-5-ol (3m). Furthermore, the proposed reaction mechanism was discussed. The developed method features simple operation, mild reaction condition, environmentally friendly, high yield and a broad range of substrate applicability. It provides a new way for the synthesis of 1,3,4-thiadiazine derivatives.
Key words: α-chloroindole, 1,3,4-thiadiazine, synthesis


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