摘要/Abstract

发展了一种通过烯基化二羰基化合物的碘环化合成多取代5-碘甲基二氢呋喃的新方法，该方法以过氧化叔丁醇（TBHP）和I₂原位形成的次碘酸和^tBuOI为活性碘正离子试剂.本反应具有反应条件温和、碘原子利用率高、试剂廉价易得等优点.
关键词: 碘环化, 烯基化二羰基化合物, 二氢呋喃, 叔丁基过氧化氢, 碘
A new method for the iodocyclization of olefinic dicarbonyl compounds with t-butyl hydroperoxide (TBHP) and I₂ was developed. The in situ generated hypoiodous acid and ^tBuOI were used as active iodine cation reagents. This method allowed the synthesis of polysubstituted 5-iodomethyldihydrofurans under mild reaction conditions with cheap reagents and high atom economy.
Key words: iodocyclization, olefinic dicarbonyl compounds, dihydrofurans, TBHP, I₂


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