摘要/Abstract

报道了通过2，3-二氯-5，6-二氰对苯醌（DDQ）介导的N-烷基二氢吲哚-2-羧酸的分子内氧化脱羧芳构化合成N-烷基吲哚.由于该方法的良好兼容性，继而开发了温和且无金属的从烷基卤化物和二氢吲哚羧酸一锅法合成N-烷基吲哚的方法.还报道了该方法在一锅法三组分合成1，4-双（（1H-吲哚-1-基）甲基）苯中的成功应用.
关键词: 芳构化, 2,3-二氯-5,6-二氰对苯醌(DDQ), 脱羧, N-烷基吲哚, 氧化
Synthesis of N-alkyl indoles via 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated intramolecular oxidative decarboxylative aromatization of N-alkylindoline-2-carboxylic acids is reported. The good compatibility of this process leads to the development of a mild and metal-free one-pot synthesis of N-alkyl indoles from alkyl halides and indoline carboxylic acid. The one-pot three-component synthesis of 1,4-bis((1H-indol-1-yl)methyl)benzene is also disclosed in satisfied yields.
Key words: aromatization, 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ), decarboxylation, N-alkyl indoles, oxidation


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