摘要/Abstract
以廉价的对苯二酚和4-甲基苯甲酸为原料, 以钯催化芳烃羧酸与芳基溴化物的分子内脱羧偶联为关键反应, 合成了具有抗疟原虫活性的天然产物pulchrol和pulchral, 总收率分别为14%和11%. 该合成为进一步研究构效关系提供了基础.
关键词: 天然产物, 全合成, 交叉偶联, pulchrol, pulchral
The total synthesis of natural products pulchrol and pulchral with antiprotozoan activity was reported, starting from the cheap hydroquinone and 4-methylbenzoic acid and using palladium-catalyzed intramolecular decarboxylation coupling reaction of arene carboxylic acids with aryl bromides as the key reaction. This method provides an opportunity for further study of the structure-activity relationship.
Key words: natural product, total synthesis, cross-coupling, pulchrol, pulchral
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