摘要/Abstract

微生物作为药物先导化合物的主要来源，在药物开发中具有重要的研究价值.从放线菌中发现了大量的活性新化合物，其中从稀有放线菌中得到的新化合物的数量呈现上升态势.对2006年1月~2018年6月报道的从陆地植物、土壤、海洋沉积物、海洋动物等来源的稀有放线菌中所发现的新活性化合物进行综述，结构类型涉及大环内酯、聚酮、蒽醌、联吡啶类、多烯等类型化合物，包括515个新天然产物.同时对稀有放线菌的生物转化也进行了综述.
关键词: 稀有放线菌, 活性化合物, 来源, 结构, 生物转化
The microbe is an important source of lead compound. It plays an important role in drug development. Many new active compounds were found from actinomycetes, and the number of new compounds from rare actinomycetes showed an upward trend. This paper introduces the new active compounds including 515 new natural products found in rare actinomycetes, from plants, soil, marine sediment, marine animals and so on. The structure type included macrolides, polyketides, anthraquinones, bipyridines, polyene, etc. The biotransformation of natural products by rare actinomycetes was reported from January 2006 to June 2018.
Key words: rare actinomycetes, activity compounds, source, structure, biotransformation


PDF全文下载地址:

点我下载PDF