摘要/Abstract
三环咔唑醌类生物碱Murrayaquinone A是从九里香属植物中分离得到的，具有强心活性.以商品化的3-乙酰基吲哚为起始原料，首次将钯催化的分子内吲哚α-C-H烯基化反应应用于咔唑天然产物A环的构建，经8步反应、以8%的总收率实现了Murrayaquinone A的全合成.
关键词: Murrayaquinone A, 咔唑生物碱, C-H烯基化, 全合成
Murrayaquinone A is a carbazolequinone alkaloid isolated from the root bark of Murraya euchrestifolia Hayata. It has been found to exhibit cardiotonic activity on heart muscle. Starting from the commercially available 3-acylindole, the total synthesis of Murrayaquinone A was realized in eight steps in an overall yield of 8%. The key step of our synthesis involves a palladium-catalyzed intramolecular α-C-H alkenylation of indole derivative to construct the carbazole A ring.
Key words: murrayaquinone A, carbazole alkaloid, C-H alkenylation, total synthesis
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