摘要/Abstract
综合运用多种现代色谱学分离方法对白芍中内生真菌Penicillium mariae-crucis的次生代谢产物进行了研究，从其发酵液的乙酸乙酯萃取部位中分离得到了10个化合物，采用多种现代波谱技术确定了这些化合物的化学结构，分别鉴定为：penicmariae-crucis A （1）、penicmariae-crucis B （2）、penicmariae-crucis C （3）、penicmariae-crucis D （4）、（E）-2-甲基己-3-烯二酸（5）、2-乙酰基-3-羟基-5-甲氧基苯乙酸（6）、2-乙酰基-3-羟基-5-甲氧基苯乙酸甲酯（7）、2-乙酰基-3，5-二羟基苯乙酸甲酯（8）、β-谷甾醇（9）、过氧化麦角甾醇（10）·其中化合物1~4为新化合物，化合物5为新天然产物，所有化合物均为首次从内生真菌P. mariae-crucis中分离得到.
关键词: 白芍, P. mariae-crucis, 内生真菌, 化学成分
Four new compounds, penicmariae-crucis A (1), penicmariae-crucis B (2), penicmariae-crucis C (3), penicmariae-crucis D (4), and a new natural product, (E)-2-methylhex-3-enedioic acid (5), together with five known compounds, O-methylcurvulinic acid (6), methyl 2-acetyl-3-hydroxy-5-methoxyphenylacetate (7), methyl 2-acetyl-3,5-dihydroxyphenyl-acetate (8), β-sitosterol (9) and ergosterol peroxide (10), were isolated from the ethyl acetate extract of endophytic fungus Penicillium mariae-crucis in Paeonia lactiflora Pall. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from P. mariae-crucis for the first time.
Key words: P. lactiflora Pall, P. mariae-crucis, endophytic fungus, chemical constituent
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