摘要/Abstract

天然产物全合成是有机化学的重要研究方向之一，具有复杂结构和重要生理活性的天然产物及其衍生物也是药物研发的重要来源.主要介绍利用化学合成与生物合成结合的策略，实现复杂天然产物的全合成及规模制备.主要内容包括青蒿素，Spinosyn A，Myceliothernophin E和Equisetin的化学与生物合成研究.
关键词: 天然产物全合成, 化学合成, 生物合成
Total synthesis of natural products is one of the most important field in organic chemistry. Natural products and derivatives, containing complex structures and potential biological activities, are also indispensable sources of drug discovery. The total synthesis of natural products through the combination of chemical synthesis and biosynthesis strategies is reviewed. The main content includes the chemical and biosynthetic studies of artemisinin, spinosyn A, myceliothernophin E and equisetin.
Key words: total synthesis of natural products, chemical synthesis, biosynthesis


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