摘要/Abstract
使用稳定易得的三氟甲硫基银作为“三氟甲硫基”源，通过苯乙烯的三氟甲硫基化/氧化反应，合成了一系列多取代α-三氟甲硫基苯乙酮.以二甲基亚砜和氯仿的为溶剂，过硫酸钾为氧化剂，通过自由基历程进行双官能化反应，在温和条件下，以中等到良好的收率实现了一系列不同取代的苯乙烯的氧化三氟甲硫基化的高效转化，为α-三氟甲硫基苯乙酮的合成提供了一种简单、步骤经济的有效合成方法.
关键词: 苯乙烯, 三氟甲硫基化, 自由基
Trifluoromethylthiolation/oxidation of styrenes with easiy-handling AgSCF3 used as the trifluoromethylthiolating reagent has been described, which furnished a series of α-trifluoromethylthio acetophenons. A variety of substituted styrene could be bifunctionalized via radical process in a mixed solvent of dimethyl sulfoxide (DMSO) and CHCl3, with potassium persulfate used as the oxidant under mild conditions. A simple and efficent method for the facile construction of various α-trifluoromethylthio acetophenons is thus demonstrated.
Key words: styrene, trifluoromethylthiolation, radical
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