摘要/Abstract

芳香伯胺类化合物在医药、农药以及材料化学中都有着广泛的应用.近年来，通过发展绿色高效C-N键构建方法引入伯胺是化学合成领域研究的热点之一.直接C-H键官能团化向目标分子中引入伯胺的策略因其高效实用的优点受到了化学家们的广泛关注.主要总结最近几年芳香C（sp²）-H伯胺化反应的研究进展，并对该领域所面临的挑战及发展前景做了总结和展望.
关键词: 氨基化, C-H键官能团化, 伯胺, 过渡金属催化
Primary anilines are widely used in pharmaceutical, agrochemicals and material chemistry. In recent years, the green and efficient methods for constructing carbon-nitrogen (C-N) bonds to introduce primary amines has been one of the hottest topics in chemical synthesis. The direct C-H primary amination of aromatic compounds have received considerable attention due to its high efficiency and practicality. The recent progress in the C-H primary amination of aromatic compounds reactions is reviewed. Furthermore, the synthetic challenge and prospect in the future development for the synthesis of primary anilines through direct C-H amination are summarized.
Key words: amination, C-H bond functionalization, primary anilines, transition-metal catalyzed


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