摘要/Abstract

直接对磷酰基邻位的C（sp³）—H键进行官能团化来合成烯基膦酸酯的研究非常少见.通过苄基膦酸酯与多聚甲醛在温和的碱性条件下，使用四叔丁基碘化铵催化可以在空气中高效简便地合成烯烃膦酸酯，底物适用范围广，可获得中等至优秀的产率.
关键词: 膦酸酯, 烯烃化, C(sp³)—H键官能团化, Horner-Wadsworth-Emmons反应
The direct functionalization of the C (sp³)—H bond adjacent to the phosphonate group for the preparation of vinyl phosphonates was rarely developed. Herein, a simple and efficient tetrabutylammonium iodide catalyzed protocol for the preparation of vinyl phosphonates from benzylic phosphonates and paraformaldehyde is achieved under mild conditions in air. Moderate to high yields can be obtained for a broad scope of substrates.
Key words: phosphonate, olefination, C(sp³)—H functionalization, Horner-Wadsworth-Emmons reaction


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