摘要/Abstract

Michael加成反应和Aldol反应是有机合成中最基本和最常见的两种反应类型.通过对反应条件的调控和底物的设计，使卤素离子（Cl^-，Br^-，I^-）对α，β-不饱和化合物发生Michael加成之后，生成的活性中间体与醛在同一体系中继续进行Aldol反应得到多官能团产物，这一反应被称为halo-Michael/Aldol串联反应.Halo-Michael/Aldol串联反应可以有效提高有机合成的原子经济性和步骤经济性.总结了不同类型路易斯酸促进的halo-Michael/Aldol串联反应及其在合成中的应用，并展望了该反应的发展趋势.
关键词: Halo-Michael/Aldol反应, 串联反应, 路易斯酸, 应用, 合成
Michael addition and aldol reaction are among the most basic and commoly used reactions. Cascade halo-Michael/Aldol reaction can effectively improve the atomic economy and step economy of organic synthesis. After the Michael addition of α,β-unsaturated compound with halide ion (Cl^-, Br^-, I^-), the reactive intermediate reacts with aldehyde through aldol reaction in the same reaction system. This process is called cascade halo-Michael/Aldol reaction. The cascade halo-Michael/Aldol reaction and its applications in the synthesis of related compounds according to the types of Lewis acid are introduced.
Key words: halo-michael/aldol reaction, cascade reaction, Lewis acid, application, synthesis


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