摘要/Abstract

N-取代1，2，3-三唑化合物在有机合成、药物化学和材料科学等领域具有广泛的应用价值.其中N¹-取代1，2，3-三唑化合物的合成方法已经非常成熟，而N²-取代1，2，3-三唑的合成报道相对较少.在现有研究报道中，主要通过1，2，3-三唑的选择性官能化及双芳腙或偶氮苯的氧化环化两类方法得到.结合我们课题组的研究工作，综述了2000年以来N²-烷基、烯丙基、炔丙基、烯基、芳基取代1，2，3-三唑的合成方法进展.
关键词: 1,2,3-三唑, 选择性N²-官能化, 烷基化, 烯丙基化, 炔丙基化, 烯基化, 芳基化, 环化
N-Substituted 1, 2, 3-triazole is an important structural unit in organic chemistry, and has widely utilized in organic synthesis, medicinal chemistry and material science. The chemistry of N¹-substituted 1, 2, 3-triazoles has attracted much attention from organic chemists, while the synthesis and application of their N²-isomers have been far less explored. The recent progress on the research field of N²-alkyl, allyl, propargyl, vinyl, aryl substituted 1, 2, 3-triazoles since year 2000 is summarized, including some research of our group. The content is classified by different synthetic methods, such as selective functionalization of 1, 2, 3-triazoles and oxidative cyclization of bisarylhydrazones or azobenzenes.
Key words: 1, 2, 3-triazole, selective N²-fuctionalization, alkylation, allylation, propargylation, vinylation, arylation, cyclization


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