摘要/Abstract
报道了分子内双锌催化剂催化的吡咯和查尔酮类化合物的不对称傅-克烷基化反应，分子内双锌催化剂由手性配体（S，S）-1和2 equiv.的二乙基锌原位反应生成.温和条件下，在15 mol%的催化剂作用下，反应以优秀的产率（高达99%）和优秀的对映选择性（对映体过量值高达99%）生成一系列β-吡咯二氢查尔酮化合物.并提出了一个可能的反应机理来解释反应的手性诱导过程.
关键词: 对映选择性催化, 傅-克烷基化, 锌, 氮杂半冠醚配体
An intramolecular dinuclear zinc complex was used in asymmetric Friedel-Crafts alkylation of pyrrole with a wide range of chalcone derivatives. This dinuclear zinc complex was prepared in situ by reacting the chiral ligand (S,S)-1 with 2 equiv. of ZnEt2. A series of β-pyrrole-substituted dihydrochalcones were formed mostly in excellent yields (up to 99%) and excellent enantioselectivities (up to >99% ee) by using 15 mol% catalyst loading under mild conditions. A possible mechanism was proposed to explain the origin of the asymmetric induction.
Key words: enantioselective catalysis, Friedel-Crafts alkylation, zinc, semi-azacrown ether ligand
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