xm:杨财广
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:yangcg@simm.ac.cn
grzy:
zjlb:研究员；****；新药；
zw:中科院上海药物所研究员、博士生导师、研究组长
txdz:上海市浦东新区祖冲之路555号
grjj: 1993-1997年在华中科技大学化学系学习，获学士学位。1997-2002年在中科院上海有机化学研究所师从姜标教授开展天然产物全合成研究，获博士学位。2002年到芝加哥大学化学系Philip E. Eaton教授小组从事有机合成方向的博士后研究。2004年起在Chuan He教授实验室开展DNA损伤修复机制方向的博士后研究。2008年入职上海药物研究所组建化学生物学研究团队，任研究员、课题组长。

yjfx:药物化学生物学。作为不同于遗传学技术研究蛋白质功能的选择性小分子工具，高质量化学探针（chemical probe）的发现和运用是药物化学生物学研究的核心内容。针对重要未靶蛋白质（untargeted protein），原创发展并充分运用化学探针，可以从生化、细胞、动物等多层面描述小分子干预这些蛋白质功能的表型和作用模式，促进未靶蛋白质的成药性确证研究。具体研究内容例如：
1、RNA甲基化修饰酶的化学探针及其抗肿瘤研究
2、小分子干预蛋白质相互作用及其抗肿瘤研究
3、新类型抗生素以及运用“非抗生素效应”控制致病菌感染的研究
dblz:1.Yue Huang, Rui Su, Yue Sheng, Lei Dong?, Ze Dong, Hongjiao Xu, Tengfeng Ni, Zijie Scott Zhang, Tao Zhang, Chenying Li, Li Han, Zhenyun Zhu, Fulin Lian, Jiangbo Wei, Qiangqiang Deng, Yungui Wang, Mark Wunderlich, Zhiwei Gao, Guoyu Pan, Dafang Zhong, Hu Zhou, Naixia Zhang, Jianhua Gan, Hualiang Jiang, James C. Mulloy, Zhijian Qian*, Jianjun Chen*, Cai-Guang Yang*. “Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia”, Cancer Cell, 2019, 35, 677-691.

2.Guijie Liu, Xing Liu, Hongjiao Xu, Xichun Liu, Hu Zhou, Zhen Huang, Jianhua Gan, Hao Chen, Lefu Lan, Cai-Guang Yang*. “Structural insights into the redox-sensing mechanism of MarR-type regulator AbfR”, J. Am. Chem. Soc. 2017, 139, 1598-1608.

3.Zhong-Qiang Guo, Tong Zheng, Baoen Chen, Cheng Luo, Sisheng Ouyang, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong, Cai-Guang Yang*, Jiang Liu*, Hualiang Jiang*. “Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer”, Cancer Cell, 2016, 30, 474-484.

4.Tengfeng Ni, Fei Ye, Xing Liu, Jie Zhang, Hongchuan Liu, Jiahui Li, Yingyi Zhang, Yinqiang Sun, Meining Wang, Cheng Luo, Hualiang Jiang, Lefu Lan, Jianhua Gan, Ao Zhang, Hu Zhou, Cai-Guang Yang*, “Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure”, ACS Chem. Biol., 2016, 11, 1964-1972.

5.Tianlu Wang, Tingting Hong, Yue Huang, Haomiao Su, Fan Wu, Yi Chen, Lai Wei, Wei Huang, Xiaoluan Hua, Yu Xia, Jinglei Xu, Jianhua Gan, Bifeng Yuan, Yuqi Feng, Xiaolian Zhang, Cai-Guang Yang*, Xiang Zhou*, “Fluorescein derivatives as bifunctional molecules for the simultaneous inhibiting and labeling of FTO protein”, J. Am. Chem. Soc. 2015, 137, 13736-13739.

6.Yue Huang, Jingli Yan, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, Cai-Guang Yang*. “Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5”, Nucleic Acids Res. 2015, 43, 373-384.

7.Jie Zhang, Hongchuan Liu, Kongkai Zhu, Shouzhe Gong, Shaynoor Dramsi, Ya-Ting Wang, Jiafei Li, Feifei Chen, Ruihan Zhang, Lu Zhou, Lefu Lan, Hualiang Jiang, Olaf Schneewind*, Cheng Luo*, Cai-Guang Yang*. “Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase”, Proc. Natl. Acad. Sci. USA. 2014, 111, 13517-13522.

8.Yue Ding, Xing Liu, Feifei Chen, Hongxia Di, Bin Xu, Lu Zhou, Xin Deng, Min Wu, Cai-Guang Yang*, Lefu Lan*, “A metabolic sensor governing bacterial virulence in Staphylococcus aureus”, Proc. Natl. Acad. Sci. USA, 2014, 111, E4981-E4990.

9.Chengqi Yi, Baoen Chen, Bo Qi, Wen Zhang, Guifang Jia, Liang Zhang, Charles Q. Li, Aaron R. Dinner, Cai-Guang Yang*, Chuan He*. “Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage”, Nat. Struct. Mol. Biol. 2012, 19, 671-676.

10.Baoen Chen, Fei Ye, Lu Yu, Guifang Jia, Xiaotian Huang, Xueju Zhang, Shuying Peng, Kai Chen, Meining Wang, Shouze Gong, Ruihan Zhang, Jinya Yin, Haiyan Li, Yiming Yang, Hong Liu, Jiwen Zhang, Haiyan Zhang, Ao Zhang, Hualiang Jiang, Cheng Luo*, Cai-Guang Yang*. “Development of Cell-active N6-Methyladenosine RNA Demethylase FTO Inhibitor”, J. Am. Chem. Soc. 2012, 134, 17963-17971.

jyjl:
gzjl:
ktxm: 2018-2022 1、国家****科学基金，**，蛋白质功能的化学干预，2018-2022，主持。