xm:邱宏
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:hongqiu@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海浦东祖冲之路555号或上海浦东蔡伦路720弄1号楼343室
grjj:2010年于中国科学院上海药物研究所获得药物化学（糖化学与糖生物学方向）博士学位，其后以博士后和Senior Research Associate的身份在美国佐治亚大学复杂碳水化合物研究中心从事科研工作。采用组学、分子细胞生物学、小鼠遗传学、基因编辑、分析化学、生物化学与分子生物学及有机化学等多学科手段研究糖及糖复合物在发育、细胞和组织稳态及疾病发生发展过程中的结构与功能，以期发现疾病诊断和治疗的新方法。研究结果发表在Nature Methods、Journal of Clinical Investigation、Molecular & Cellular Proteomics、Journal of Biological Chemistry、Oncogene、Biomacromolecules等主流学术期刊。研究得到美国心脏协会（American Heart Association）博士后基金（Postdoctoral Research Fellowship）和早期职业生涯发展奖（Scientist Development Grant, SDG）的资助。

yjfx:糖及糖复合物的结构与功能和以此为基础的新型诊疗手段的开发和应用。

dblz:1. Qiu H, Shi SS, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L (2018). A mutant cell library for systematic analysis of heparan sulfate structure-function relationships. Nature Methods. 15（11）889-899.
2. Qiu H, Shi S, Wang S, Peng H, Ding S, Wang L (2018). Proteomic profiling exosomes from vascular smooth muscle cells. Proteomics Clinical Applications. 2018 Apr 24:e**.
3. Thieker DF, Xu Y, Chapla D, Nora C, Qiu H, Felix T, Wang L, Moremen KW, Liu J, Esko JD, Woods RJ. Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase. Scientific Reports. 2018 Aug 7;8(1):11832.
4. Zhao W, Zhu T, Cheng R, Liu Y, He J, Qiu H, Wang L, Nagy T, Querec TD, Unger ER, Mao L (2016). Label-Free and Continuous-Flow Ferrohydrodynamic Separation of Hela Cells and Blood Cells in Biocompatible Ferrofluids. Advanced Functional Materials. 26(22):3990-3998.
5. Guo C, Fan X, Qiu H, Xiao W, Wang L, Xu B (2015). High-resolution probing heparan sulfate-antithrombin interaction on single endothelial cell surface: Single-molecule AFM studies. Physical Chemistry Chemical Physics. 17(30): 13301-13306.
6. Qiu H, Xiao WY, Yue, JW, Wang L (2015). Heparan sulfate regulates slit3 induced endothelial cell migration. Methods in Molecular Biology. 1229:549-555.
7. Xiao F, Qiu H, Cui HX, Ni XY, Li J, Liao WF, Lu LN, Ding K (2015). MicroRNA-885-3p inhibits growth of xenografted colon cancer HT-29 cells by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling. Oncogene. 34(15):1968-1978.
8. Zhang B, Xiao WY, Qiu H, Wang L et al. (2014) Congenital-Diaphragmatic-Hernia Results from Disruption of Slit3-Robo4-Heparan Sulfate Signaling-elicited Developmental Angiogenesis. Journal of Clinical Investigation. 124(1):209-221
9. Qiu H, Jiang J, Liu M, Huang X, Ding SJ, Wang L (2013). Quantitative Phosphoproteomics Reveals Broad Regulatory Roles of Heparan Sulfate on Endothelial Signaling. Molecular Cellular Proteomics. 12(8):2160-2173
10. Xiao F, Qiu H, Zhou L, Shen X, Yang L, Ding K (2013). WSS25 inhibits Dicer, downregulating microRNA-210 which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology. 23(5):524-535.
11. Zhang S, Condac E, Qiu H, Jiang J, Gutierrez-Sanchez G, Bergmann C, Handel T, Wang L (2012). Heparin-Induced Leukocytosis Requires 6-O-Sulfation and is Caused by Blockade of Selectin- and CXCL12-Mediated Leukocyte Trafficking in Mice. Journal of Biological Chemistry. 287(8):5542-5553.
12. Xu YX, Dong Q, Qiu H, Ma CW, Ding K (2011). A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom. Carbohydrate Research. 346(13):1930-1936.
13. Xu YX, Dong Q, Qiu H, Ding K (2010). Structure elucidation of an arabinogalactan from Platycodon grandiflorum roots and anti-angiogenic activity of its sulfated derivatives. Biomacromolecules. 11(10): 2558-2566.
14. Qiu H, Yang B, Pei ZC, Zhang Z, Ding K. (2010). WSS25 repressed hepatocarcinoma growth through disrupting tumor angiogenesis via blocking the BMP/Smad/Id1 signaling. Journal of Biological Chemistry. 285(42): 32638-32646.
15. Tong XK*, Qiu H* Tang W, Ding K, Zuo JP et al (2010). WSS45, a sulfated α-D-glucan from Gastrodia elata Bl., strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacologica Sinica. 31(5): 585-592. *, Co-first author.
16. Zhang Z, Wang S, Qiu H, Duan CH, Ding K, Wang ZT (2009). Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. Cancer Letters. 286(2):223-31.
17. Qiu H*, Tang W*, Tong X, Ding K, Zuo J (2007). Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydrate Research. 342(15):2230-6. *, Co-first author.

jyjl:1999.9-2003广州中医药大学，学士