中国科学院上海药物研究所导师教师师资介绍简介-文留青

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xm:文留青
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:lwen@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:
grjj:　　文留青，2017年毕业于佐治亚州立大学化学系，获得博士学位。之后在佐治亚州立大学从事博士后研究。2019年9月加入上海药物所，任研究员，课题组长。主要从事糖化学和糖生物学的研究。致力于发展高效而又经济的合成方法合成稀有单糖和复杂寡糖，发展以寡糖为基础的寡糖药物；发展新型的技术手段研究寡糖与疾病的关系，并在此基础上从事基于糖的药物新靶标和新药发现研究。获得2016年佐治亚州立大学年度最优秀研究生，2017年国家优秀自费留学生奖学金等荣誉。

yjfx:基于寡糖的药物研究和新药靶点发现

dblz:代表论著(*Corresponding authors)：

1.Zhang, J. B.#; Chen, C. C.#, Gibbons, C.; Gadi, M. R.; Guo,Y. X., Wang, S. S., Liu, D., Wen, L.Q.* Wang, P. G.* Machine Driven Enzymatic Oligosaccharide Synthesis by a peptide synthesizer. Angew. Chem. Int. Ed. 2018, 57, 16638-16642. Frontispiece; Hot paper; Highlighted by X-MOL

2.Wen, L.Q.*; Gadi, R. M.; Zheng, Y.; Gibbons, C.; Kondengaden, S. M.; Zhang, J. B.; Wang, P. G.* Chemoenzymatic Synthesis of Unnatural Nucleotide Sugars for Enzymatic Biorthogonal Labeling. ACS Catal. 2018, 8 (8), 7659-7666. Highlighted by X-MOL

3.Wen, L.Q. #*; Edmunds, G. #; Gibbons, C. #; Zhang, J. B. #; Gadi, M. R.; Zhu, H. L.; Fang, J. Q.; Liu, X. W.; Kong, Y.; Wang, P. G.* Toward Automated Enzymatic Synthesis of Oligosaccharides. 2018, Chem. Rev. 2018, 118, 17, 8151 Invited review

4.Wen, L.Q.*; Liu, D. Zheng, Y.; Huang, K.; Cao, X. F., Song, J.; Wang, P. G.* A One-step Chemoenzymatic Labeling Strategy for Probing Sialylated Thomsen-Friedenreich Antigen. ACS Centra. Sci, 2018, 4, 451-457 Highlighted by NIH common fund (Glycoscience Program Highlights); Highlighted by ACS central science (ACS Cent. Sci. 4, 4, 428-430).

5.Wen, L.Q.; Zheng, Y.; Jiang, K.; Zhang, M. Z.; Kondengaden, S. M.; Li, S. S.; Huang, K.; Li, J.; Song, J.; Wang, P. G. Two-Step Chemoenzymatic Detection of N-Acetylneuraminic Acid-alpha(2-3)-Galactose Glycans. J. Am. Chem. Soc. 2016, 138, 11473.

6. Liu, Y. P.; # Wen, L.Q.; # Li, L.; Gadi, M. R.; Guan, W. Y.; Huang, K.; Xiao, Z. Y.; Wei, M. H.; Ma, C.; Zhang, Q.; Yu, H.; Chen, X.; Wang, P. G.; Fang, J. Q. A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids. Eur. J. Org. Chem. 2016, 4315. (contribute equally)

7.Wen, L.Q. *; Huang, K.; Zheng, Y.; Fang, J. Q.; Kondengaden, S. M.; Wang, P. G. * Two-step enzymatic synthesis of 6-deoxy-L-psicose. Tetrahedron Lett. 2016, 57, 3819.

8.Wen, L.Q.; Huang, K.; Zheng, Y.; Liu, Y. P.; Zhu, H.; Wang, P. G. A two-step strategy for the preparation of 6-deoxy-l-sorbose. Bioorg. Med. Chem. Lett. 2016, 26, 218.

9.Wen, L.Q.; Zheng, Y.; Li, T. H.; Wang, P. G. Enzymatic synthesis of 3-deoxy-d-manno-octulosonic acid (KDO) and its application for LPS assembly. Bioorg. Med. Chem. Lett. 2016, 26, 2825.

10.Wen, L.Q.; Huang, K.; Liu, Y. P.; Wang, P. G. Facile Enzymatic Synthesis of Phosphorylated Ketopentoses. ACS. Catal. 2016, 6, 1649.

11.Wen, L.Q.; Zang, L. L.; Huang, K.; Li, S. S.; Wang, R. L.; Wang, P. G. Efficient enzymatic synthesis of L-rhamnulose and L-fuculose. Bioorg. Med. Chem. Lett. 2016, 26, 969.

12.Wen, L.Q.; Huang, K.; Wei, M. H.; Meisner, J.; Liu, Y. P.; Garner, K.; Zang, L. L.; Wang, X.; Li, X.; Fang, J. Q.; Zhang, H. C.; Wang, P. G. Facile Enzymatic Synthesis of Ketoses. Angew. Chem. Int. Ed. 2015, 54, 12654. Highlighted by “Atlas of Science”

13.Li, T. H.; # Wen, L.Q.; # Williams, A.; Wu, B. L.; Li, L.; Qu, J. Y.; Meisner, J.; Xiao, Z. Y.; Fang, J. Q.; Wang, P. G. Chemoenzymatic synthesis of ADP-d-glycero-beta-d-manno-heptose and study of the substrate specificity of HldE. Biorg. Med. Chem. 2014, 22, 1139. (contribute equally)

jyjl:2013.1–2015.5 佐治亚州立大学化学硕士