?基本信息
姓名： 张琳 性别： 女 出生年月：1984.05
民族：汉族 政治面貌： 中共党员 学位：博士
毕业院校及专业： 中南大学 应用化学专业 职称：讲师
出国留学经历：美国加州州立大学洛杉矶分校化学与生物化学系
邮箱：zhanglin840514@126.com
?主要研究方向：
1.食用植物中的活性分子对阿尔茨海默病病人病症的缓解和治疗作用研究；
2.功能性食用胶体研究；
3.现代分析方法在食品分子营养领域的应用研究。
?主持科研项目：
1、国家自然科学基金青年项目，**、小鼠脑内不同Ab聚集物的分型成像和靶向给药研究、2016/01-2018/12
2、湖南省自然科学基金青年项目，2015JJ3177、具有抗AD功效的米糠多酚的筛选及其对神经细胞的保护作用研究、2015/01-2017/12
3、湖南省教育厅科学研究项目, 14C1184、水稻谷壳中黄酮类化合物通过干预Aβ自聚集抑制Aβ诱导的神经元凋亡的机理研究、2014/09-2016-09
4、长沙市科技计划项目，k**-31 表面等离子体共振技术筛选具有抗阿尔茨海默病功能的黄酮类化合物及其成果产业化2014.6-2016.6
?获奖情况：
1.2017年湖南省自然科学一等奖， 排名第三；
2.国家科技部创新团队骨干成员，排名第五。
?发表论文：
(1) Tao Yang, Fang Zhu, Tianxiao Zhou, Jianzhong Cao, Meiyi Zhang, Dong-Sheng Cao, Qinlu Lin, Lin Zhang*, Label-Free, Water-Soluble Fluorescent Peptide Probe for Sensitive and Selective Determination of Copper Ions, Analytical Sciences, 33: 191-196, 2017
(2)Lin Zhang, Yuanqiang Hao, Xiaoying Wang, Yunfei Long, Angela Ramos, Dianlu Jiang, Xiaohua Ma, Qinlu Lin and Feimeng Zhou*, Optically transparent electrodes modified with sulfide ion-covered CdS quantum dots for sensitive photoelectrochemical detection of sulfhydryl-containing compounds, Electroanalysis, 27, (8): 1899-1905, 2015
(3). Lin Zhang, Gargey Yagnik, Yong Peng, Jianxiu Wang, H. Howard Xu, Yuanqiang Hao, You-Nian Liu, and Feimeng Zhou*, Kinetic studies of inhibition of the amyloid beta (1–42) aggregation using a ferrocene-tagged β-sheet breaker peptide, Analytical Biochemistry, 434 (2): 292-299, 2013
(4). Lin Zhang, Tianhan Kai, Zhifang Sun, Yuanqiang Hao, Qiuyun Tu, and Feimeng Zhou*, A ferrocene-tagged amyloid-β fragment for rapid screening of aggregation inhibitors from natural compounds by HPLC-electrochemical detection, Electroanalysis, 25 (7): 1659-1664, 2013
(5). Lin Zhang, Gargey Yagnik, Dianlu Jiang, Shuyun Shi, Peter Chang, and Feimeng Zhou*, Separation of intermediates of iron-catalyzed dopamine oxidation reactions using reversed-phase ion-pairing chromatography coupled in tandem with UV–visible and ESI-MS detections, Journal of Chromatography B, 911, 55-58, 2012
(6). Dianlu Jiang, Lin Zhang（并列第一作者）, Gian Paola G. Grant, Christopher G. Dudzik, Shu Chen, Sveti Patel, Yuanqiang Hao, Glenn L. Millhauser, and Feimeng Zhou*, The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques, Biochemistry, 52 (3): 547-556, 2013
(7) 张琳，林亲录，阳明辉，β-淀粉样多肽自聚集抑制剂的电化学筛选方法研究，化学传感器，33 (4):23-28, 2013
(8) 周天啸，刘馥歌，杨涛，张琳*，自组装多肽水凝胶包埋大蒜精油的控释研究，粮食与油脂，29:14-18, 2016
(9) 张琳，周天啸，王奔，郝雅晏，陆俊*，Fmoc-F多肽水凝胶对丁香精油的控释作用研究，食品与机械，32, 8-11, 2016
(10) 张琳，肖华西，丁玉琴，林亲录，研讨式教学在食品科学类专业课程中的应用研究，教育教学论坛，2：155-156，2018
(11). Tianhan Kai, Lin Zhang，Xiaoying Wang, Aihua Jing, Bingqing Zhao, Xiang Yu, Jie Zheng, Feimeng Zhou, Tabersonine inhibits amyloid fibril formation and cytotoxicity of Aβ (1–42), ACS Chemical Neuroscience, 6: 879-884, 2015
(12). Shu Chen, Lin Zhang, Yunfei Long, and Feimeng Zhou*, Electroanalytical sensors and methods for assays and studies of neurological biomarkers, Electroanalysis, 26(6): 1236–1248, 2014.
(13). Jie Dong, Zhi?Jiang Yao, Lin Zhang,Feijun Luo, Qinlu Lin, Ai?Ping Lu, Alex F. Chen and Dong?Sheng Cao1*, PyBioMed: a python library for various molecular representations of chemicals, proteins and DNAs and their interactions, Journal of Cheminformatics, 10 (16): ,2018
(14). Dianlu Jiang, Shuyun Shi, Lin Zhang, Lin Liu, Bingrong Ding, Bingqing Zhao, Gargey Yagnik, and Feimeng Zhou*, Inhibition of the Fe(III)-catalyzed dopamine oxidation by ATP and its relevance to oxidative stress in Parkinson’s Disease, ACS Chemical Neuroscience, 4 (9): 1305-1313, 2013
(15). Chuan-Wan Wei, Yong Peng, Lin Zhang, Qiyu Huang, Ming Cheng, You-Nian Liu*, Juan Li, Synthesis and evaluation of ferrocenoyl pentapeptide (Fc-KLVFF) as an inhibitor of Alzheimer’s Ab(1–42) fibril formation in vitro, Bioorganic & medicinal chemistry letters, 21 (19): 5818-5821, 2011
(16). Chengshan Wang, Lin Liu, Lin Zhang, Yong Peng, and Feimeng Zhou*, Redox reactions of the a-synuclein-Cu2+ complex and their effects on neuronal cell viability, Biochemistry, 49 (37): 8134–8142, 2010
(17). Yin-Hua Deng, Ning-ning Wang, Zhen-xing Zou, Lin Zhang, Kang-Ping Xu, Alex F. Chen, Dong-Sheng Cao*, and Gui-Shan Tan*, Multi-target screening and experimental validation of natural products from selaginella plants against Alzheimer’s Disease, Frontiers in Pharmacology, 8, article 539, 2017
(18). Yong Peng, Dianlu Jiang, Lei Su, Lin Zhang, Ming Yan, Juanjuan Du, Yufeng Lu, You-Nian Liu, and Feimeng Zhou*. Mixed monolayers of ferrocenylalkanethiol and encapsulated horse radish peroxidase for sensitive and durable electrochemical detection of hydrogen peroxide. Analytical Chemistry, 81 (24): 9985–9992, 2009
(19). Ling-Bin Ou, You-Nian Liu*, Jianxiu Wang, and Lin Zhang, Enhanced voltammetric detection of epinephrine at a carbon nanotube/nafion composite electrode in the presence of ascorbic acid, Journal of Nanoscience and Nanotechnology, 9 (11): 6614-6619, 2009
(20) Tao Yang, Huifen Huang, Fang Zhu, Qinlu Lin, Lin Zhang, and Junwen Liu, Recent progresses in nanobiosensing for food safety analysis, Sensors, 16, 1118, 2016
(21) Huaxi Xiao, Tao Yang, Qinlu Lin, Gao-qiang Liu, Lin Zhang, Fengxiang Yu, and Yuejiao Chen, Acetylated starch nanocrystals: preparation and antitumor drug delivery study, International journal of biological macromolecules, 89: 456-464, 2016