周童1,2,
王娟1,2,
刘颖1,2,
许平3,
许安1,2,,
1. 中国科学院合肥物质科学研究院, 环境毒理与污染控制技术安徽省重点实验室, 合肥 230031;
2. 中国科学技术大学, 合肥 230026;
3. 合肥市第一人民医院, 合肥 230061
作者简介: 丁晗(1992-),女,硕士研究生,研究方向为环境毒理学,E-mail:1907026150@qq.com.
通讯作者: 许安,anxu@ipp.ac.cn
基金项目: 国家自然科学基金重大研究计划培育项目（91743106）中图分类号: X171.5
Research Progress on the Effects of Typical Environmental Pollutants on Gut Microbiota and Their Underlying Mechanisms
Ding Han1,2,Zhou Tong1,2,
Wang Juan1,2,
Liu Ying1,2,
Xu Ping3,
Xu An1,2,,
1. Hefei Institutes of Physical Science, Chinese Academy of Sciences, Environmental Toxicology and Pollution Control Technology Key Laboratory of Anhui Province, Hefei 230031, China;
2. University of Science and Technology of China, Hefei 230026, China;
3. Hefei First People's Hospital, Hefei 230061, China
Corresponding author: Xu An,anxu@ipp.ac.cn
CLC number: X171.5
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摘要:随着环境污染日益严重，国内外有关环境污染物导致健康风险的毒性机制研究已引起广泛关注。然而，环境污染物对机体肠道菌群结构、功能的改变及其对毒性效应的调控作用研究尚处起步阶段。本综述在归纳近年来国内外人体及模式生物的肠道菌群研究进展的基础上，重点阐述了以重金属污染物、微纳米颗粒污染物、持久性有机污染物以及抗生素为代表的典型环境污染物对肠道菌群结构、组成、数量以及代谢等的影响，总结了肠道菌群在机体毒性效应中潜在调控作用，为后续肠道菌群在环境污染物毒理学效应及人类健康风险方面的系统研究提供理论参考。
关键词: 环境污染物/
肠道菌群/
毒性效应/
机制
Abstract:With the increasingly serious environmental pollution, studies on the toxicological mechanisms of environmental pollutants leading to health risks has caused great concerns. However, the investigation on how environmental pollutants affect the structure and function of the gut microbiota and its regulation of toxic effects is still largely unknown. Based on the characteristics of gut microbiota in the human and animal models, this paper focused on the structure, diversity and composition of gut microbiota altered by typical environmental pollutants including heavy metals, micro-nano particle, persistent organic pollutants and antibiotics. In addition, the potential regulatory role of gut microbiota in the toxicological effects of organisms were summarized. It provided a theoretical basis for subsequent systematic studies on gut microbiota regulated toxicological effects of environmental pollutants and human health risks.
Key words:environmental pollutants/
gut microbiota/
toxicological effects/
mechanism.
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