张瀚心3,
张效伟2,,
1. 流域环境生态工程研发中心, 北京师范大学自然科学高等研究院, 珠海 519087;
2. 污染控制与资源化研究国家重点实验室, 南京大学环境学院, 南京 210023;
3. 生态环境部固体废物与化学品管理技术中心化学品部, 北京 100029
作者简介: 彭颖(1985-),女,博士,副研究员,研究方向为生态毒理与生物地球化学,E-mail:pengying2009@live.cn.
通讯作者: 张效伟,zhangxw@nju.edu.cn
基金项目: 国家重点研发计划课题（2018YFC1801606，2018YFC1801605）；国家自然科学基金资助项目（21707069，41977206）中图分类号: X171.5
Research Advance of Quantitative Adverse Outcome Pathways (qAOPs) in Environmental Chemicals Toxicity Assessment Ⅰ: Model Building and Application Cases
Peng Ying1,2,Zhang Hanxin3,
Zhang Xiaowei2,,
1. Research and Development Center for Watershed Environmental Eco-Engineering, Advanced Institute of Natural Sciences, Beijing Normal University, Zhuhai 519087, China;
2. State Key Laboratory of Pollution Control&Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China;
3. Solid Waste and Chemicals Management Center, Ministry of Ecology and Environment, Beijing 100029, China
Corresponding author: Zhang Xiaowei,zhangxw@nju.edu.cn
CLC number: X171.5
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摘要:近年来，有害结局路径（adverse outcome pathway，AOP）框架逐渐发展成熟，将生物信息组织成一种可用于评估化学品对人体健康和生态环境生物毒性的新方法，其开发的目的是用于化学品的评估和监管工作，包括优先级评估和危害性预测，最终实现风险评估并服务于管理决策。尽管AOP框架取得了巨大进展，但将其有效应用于化学品监管需要对分子启动事件、关键事件和有害结局之间的关系进行定量描述，因此发展定量AOPs （quantitative AOPs，qAOPs）至关重要。本文首先概述了AOP框架的现状，包括AOP数据库（AOP Knowledge Base）、定性AOPs （qualitative AOPs）和qAOPs。其次主要介绍了qAOPs构建的基本框架与步骤、方法模型，现阶段已构建的qAOPs案例及其应用现状。最后论述了当前qAOPs发展中存在的问题与潜在解决方案，并展望了未来的发展趋势与潜在应用。
关键词: 化学品风险评估/
预测毒理学/
定量有害结局路径/
混合物危害评估
Abstract:Over the past decade, the development of adverse outcome pathway (AOP) framework has matured significantly, which has been considered as a new approach for organizing biological information into a format and applicable method for chemical safety evaluation in both human health and ecological contexts. Ultimately, it is developed for use in the assessment and regulation of chemicals, including the priority assessment and hazard prediction. Based on above, AOP will contribute to the realization of the risk assessment and application in regulatory decision making. Although the development of AOP frameworks has made great progress, its effective application to chemical regulation requires a detailed quantitative description of the relationship among the molecular priming events, key events and the adverse outcome. Consequently, quantitative AOPs (qAOPs) is critical for AOP application. At first, this review summarizes the development status of AOP framework, including AOP knowledge base (AOP KB), qualitative AOPs and quantitative AOPs. Secondly, this review describes how qAOP models can be developed and provides examples of how they could be used in a hazard or risk assessment context. Finally, the most important issues and potential solutions in the current qAOPs development process are discussed in this review, the future research and application of qAOPs in the hazard assessment of environment chemicals and environmental mixtures are also prospected.
Key words:chemical risk assessment/
predictive toxicology/
quantitative adverse outcome pathway/
mixture risk assessment.
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