) 认知与人格教育部重点实验室, 重庆 400715
收稿日期:2020-04-27出版日期:2021-02-15发布日期:2020-12-29通讯作者:高军E-mail:gaojunscience@126.com基金资助:国家自然科学基金(32071059);重庆市自然科学基金(cstc2020jcyj-msxmX0209);中央高校基本科研业务费专项资金(SWU1909326)Effects of oxytocin on psychological resilience: The neurochemical mechanisms in the hippocampus
XUE Bing, WANG Xuejiao, MA Ning, GAO Jun() Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing 400715, China
Received:2020-04-27Online:2021-02-15Published:2020-12-29Contact:GAO Jun E-mail:gaojunscience@126.com摘要/Abstract
摘要： 心理韧性指个体面对逆境、挫折或重大威胁等应激情境下的有效且灵活适应的能力, 促进机体恢复正常的生理和心理功能。研究表明海马是调控心理韧性的重要脑区, 且催产素可能通过作用于海马增强心理韧性。海马内部环路内嗅皮层-齿状回-CA3可能调节恐惧记忆的泛化和消退以增强心理韧性; 海马外部环路齿状回-杏仁核-伏隔核及海马-伏隔核环路调节情绪, 可能分别通过促进奖赏和带来厌恶进而增强或降低心理韧性。催产素作用于海马增强心理韧性的可能途径有:催产素促进海马神经发生, 降低海马腹侧成熟神经元对应激的敏感性, 提高海马“模式分离”功能, 降低应激记忆泛化; 催产素恢复海马谢弗侧枝-CA1突触长时程增强, 促进机体适应应激; 催产素降低海马糖皮质激素受体水平, 重新建立机体稳态。
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