刘小歌^1,2， 张 伦^1,2， 于晓琳^1*

1. 中国科学院过程工程研究所生化工程国家重点实验室，北京 100190
2. 中国科学院大学化学与化工学院，北京 100049

收稿日期:2018-05-17修回日期:2018-06-22出版日期:2018-10-22发布日期:2018-10-12
通讯作者:于晓琳

基金资助:国家重大新药创制专项;国家重大新药创制专项;战略性先导科技专项

The role of microglia in Alzheimer's disease

Xiaoge LIU^1,2, Lun ZHANG^1,2, Xiaolin YU^1*

1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190,China
2. School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2018-05-17Revised:2018-06-22Online:2018-10-22Published:2018-10-12

摘要/Abstract

摘要： 阿尔兹海默病(老年性痴呆，AD)是由β淀粉样蛋白(Aβ)和微管相关蛋白(Tau)聚集形成的具有毒性作用的寡聚物而引起的老年人主要以记忆力下降和脑部形成老年斑、神经纤维缠绕为特征的神经退行性疾病. 小胶质细胞作为中枢神经系统中的固有免疫细胞，是脑内免疫监视的关键成分，发挥内源性免疫防御作用. 正常生理状态的小胶质细胞能有效吞噬和清除毒性Aβ寡聚体，阻止AD发生. 在AD病理过程中，过度激活的小胶质细胞通过补体依赖途径过度吞噬突触，导致突触丧失，同时大量释放炎症因子，促进Tau相关病理变化，对神经元造成直接损伤，导致认知功能下降. 由此可见，小胶质细胞在AD发生发展过程中起着双刃剑的作用，探明小胶质细胞的极化状态及其在AD疾病机理中的作用将为攻克AD的药物研发提供突破性思路.

引用本文

刘小歌 张伦 于晓琳. 小胶质细胞对阿尔兹海默病发生发展的影响作用[J]. 过程工程学报, 2018, 18(5): 900-907.
Xiaoge LIU Lun ZHANG Xiaolin YU. The role of microglia in Alzheimer's disease[J]. Chin. J. Process Eng., 2018, 18(5): 900-907.

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