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Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor rib
HongweiSun1,1,ShengyaoZhi1,1,GuifangWu1,GuanglanWu1,TianqiCao1,HuHao2,ZhouSongyang3,4,5,6,PupingLiang7,8,JunjiuHuang9,10,111MOEKeyLaboratoryofGeneFunc ...
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A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers s
KaiqinLia,b,YifanLia,b,JunyangWanga,b,YongxiaHuoa,DiHuanga,ShiwuLia,b,JieweiLiua,XiaoyanLia,b,RongLiua,c,XiaogangChend,Yong-GangYaoa,b,e,f,CeshiChena, ...
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Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst comp
XiaominWanga,b,1,HuiShia,b,1,JuanjuanZhoua,i,1,QingjianZouf,QuanjunZhanga,c,d,e,ShixueGoua,b,PengfeiCheng,h,LishaMoug,NanaFana,c,d,e,YangyangSuoa,j,Zh ...
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CRISPR/Cas9-mediated disruption of TaNP1 genes results in complete male sterility in bread wheat
JianLia,1,ZhengWanga,1,GuangmingHeb,LigengMac,XingWangDenga,baPekingUniversityInstituteofAdvancedAgriculturalSciences,Weifang,Shandong,261325,ChinabSt ...
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Investigation of CRISPR/Cas9-induced SD1 rice mutants highlights the importance of molecular charact
SukumarBiswasa,JiaqiTiana,RongLia,XiaofeiChena,ZhijingLuoa,MingjiaoChena,XiangxiangZhaob,DabingZhanga,b,StaffanPerssona,c,ZhengYuana,b,JianxinShiaaJoi ...
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A novel pathogenic mutation in FBN2 associated with congenital contractural arachnodactyly for preim
JiaxinLi1,1,YuqianWang2,3,1,XiaohuiZhu2,3,YanliNie2,3,YingKuo2,3,ShuoGuan2,3,JinHuang2,3,YingLian2,3,YangyuZhao2,3,RongLi2,3,YuanWei4,JieQiao5,6,7,8,L ...
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Dissection of the genetic mechanisms underlying congenital anal atresia in pigs
KaiJiang1,2,YuyunXing3,PanXu3,QiangYang3,ChuanminQiao3,WeiweiLiu3,HaoChen3,YuyongHe3,JunRen3,1,LushengHuang31StateKeyLaboratoryofPigGeneticImprovement ...
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Single-cell RNA sequencing identifies novel cell types in Drosophila blood
YulongFua,1,XiaohuHuanga,c,1,PengZhangb,JoycevandeLeemputa,c,ZheHana,caCenterforPrecisionDiseaseModeling,DepartmentofMedicine,UniversityofMarylandScho ...
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Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading
KunDoua,b,YanchaoLiuc,1,YingpeiZhangc,1,ChenhuiWanga,YingHuangc,d,ZZZhaoZhanga,e,faDepartmentofEmbryology,CarnegieInstitutionforScience,Baltimore,MD,2 ...
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Mutation of DELAYED GREENING1 impairs chloroplast RNA editing at elevated ambient temperature in Ara
JingliangSuna,b,YingyingTianb,QichaoLiana,Jian-XiangLiua,baStateKeyLaboratoryofGeneticEngineering,SchoolofLifeSciences,FudanUniversity,Shanghai,200433 ...
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CTP synthase forms cytoophidia in archaea
ShuangZhoua,b,c,HuaXiangb,d,Ji-LongLiuaaSchoolofLifeScienceandTechnology,ShanghaiTechUniversity,Shanghai,201210,ChinabUniversityofChineseAcademyofScie ...
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Resident endothelial cells generate hepatocytes through cell fusion in adult mouse liver
WenjuanPu1,2,1,XimengHan1,2,1,MingjunZhang1,2,YanLi1,2,XiuzhenHuang1,2,LingjuanHe1,2,BinZhou3,41StateKeyLaboratoryofCellBiology,ShanghaiInstituteofBio ...
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Severe cases of BCGosis-susceptible primary immunodeficiency diseases identified by next-generation
GangLiu1,1,HaijuanXiao1,1,LinlinLiu1,LingyunGuo1,RuolanGuo2,XuyunHu2,ChanjuanHao2,JingangGui2,WeiweiJiao2,FangXu2,AdongShen2,WeiLi21DepartmentofInfect ...
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Lessons from expanded potential of embryonic stem cells: Moving toward?totipotency
RongrongLe,YixinHuang,AnqiZhao,ShaorongGaoClinicalandTranslationalResearchCenterofShanghaiFirstMaternity&InfantHospital,FrontierScienceCenterforStemCe ...
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The proline synthesis enzyme P5CS forms cytoophidia in Drosophila
BoZhanga,b,c,1,?mürY.Tastand,1,XianZhoua,1,Chen-JunGuoa,XuyangLiua,e,AaronThindd,Huan-HuanHua,SuwenZhaoa,e,Ji-LongLiua,daSchoolofLifeScienceandTechnol ...
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Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans
RuofengTanga,b,c,XinWangc,JunxiangZhoua,b,c,FengxiaZhangd,ShanZhaoc,QiwenGana,b,c,LiyuanZhaoa,b,FengyangWanga,b,QianZhanga,b,JieZhangc,GuodongWangd,Ch ...
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Two homologous INDOLE-3-ACETAMIDE (IAM) HYDROLASE genes are required for the auxin effects of IAM in
YangbinGaoa,XinhuaDaia,YukiAoig,YumikoTakebayashib,LipingYanga,c,XiaoruiGuoa,d,QiweiZenga,e,HanchuanzhiYua,HiroyukiKasaharab,f,YundeZhaoaaSectionofCel ...
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Clinical utility of whole genome sequencing for the detection of mitochondrial genome mutations
AmmarHusami1,JesseSlone1,JeniceBrown1,MeghanBromwell1,C.AlexanderValencia2,3,4,5,TaoshengHuang61DivisionofHumanGenetics,Children'sHospitalMedicalCente ...
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Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA
Anne-MarieMadore1,LucilePain1,Anne-MarieBoucher-Lafleur1,AndréanneMorin2,3,JolyaneMeloche4,Marie-MichelleSimon5,BingGe6,7,TonyKwan6,7,WarrenA.Cheung6, ...
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Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and dise
RaoxuWanga,b,BowenLic,SinManLama,c,GuanghouShuia,baStateKeyLaboratoryofMolecularDevelopmentalBiology,InstituteofGeneticsandDevelopmentalBiology,Chines ...
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Defining endogenous barcoding sites for CRISPR/Cas9-based cell lineage tracing in zebrafish
ChangYe1,ZhuoxinChen1,ZhanLiu,FengWang,XiongleiHeStateKeyLaboratoryofBiocontrol,SchoolofLifeSciences,SunYat-senUniversity,Guangzhou,510275,ChinaMoreIn ...
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Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbal
AdamF.Johnsona,c,JieHoub,HuaYangc,XiaowenShic,ChenChenb,MdSolimanIslamb,TiemingJid,JianlinChengb,JamesA.BirchlercaInstituteofResearchandDevelopment,Du ...
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Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-
TingGonga,1,XinGua,1,Yu-TingLiua,ZhenZhoua,Ling-LiZhanga,YangWena,Wei-LiZhonga,Guo-LiangXua,Jin-QiuZhoua,baStateKeyLaboratoryofMolecularBiology,CASCen ...
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Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) a
TianyiQiu1,1,TiantianMao2,1,YuanWang2,MengdiZhou2,JingxuanQiu2,JianweiWang3,JianqingXu4,ZhiweiCao51ShanghaiPublicHealthClinicalCenter,FudanUniversity, ...
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Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines
XinLiu1,Xiu-JieWang2,3,41KeyLaboratoryofGeneticNetworkBiology,InstituteofGeneticsandDevelopmentalBiology,ChineseAcademyofSciences,Beijing,100101,China ...
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Engineering T cells for immunotherapy of primary human hepatocellular carcinoma
LeidyD.CaraballoGalvaa,LunCaia,YanxiaShaoa,YukaiHea,baGeorgiaCancerCenter,MedicalCollegeofGeorgia,AugustaUniversity,Augusta,GA,30912,USAbDepartmentofM ...
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Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropa
QianruHuang,XuLiu,YujiaZhang,JingyaoHuang,DanLi,BinLiShanghaiInstituteofImmunology,DepartmentofImmunologyandMicrobiology,ShanghaiJiaoTongUniversitySch ...
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Structural and immunogenomic insights into B-cell receptor activation
YangyangFeng,YuWang,ShaocunZhang,KabeerHaneef,WanliLiuMOEKeyLaboratoryofProteinSciences,CenterforLifeSciences,CollaborativeInnovationCenterforDiagnosi ...
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Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically in
FenghuaZhanga,b,XianmeiLia,b,MudanHea,b,DingYea,b,FengXionga,b,GolpourAmina,b,ZuoyanZhua,b,YonghuaSuna,baStateKeyLaboratoryofFreshwaterEcologyandBiote ...
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Genome-wide evolution analysis reveals low CpG contents of fast-evolving genes and identifies antivi
WenhongZua,b,HangZhanga,b,XunLanc,e,XuTana,b,d,eaMOEKeyLaboratoryofBioorganicPhosphorusChemistry&ChemicalBiology,SchoolofPharmaceuticalSciences,Tsingh ...
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Arabidopsis EED1 encoding a plant-specific nuclear protein is essential for early embryogenesis
MaiYang1,1,ChunYan2,1,MeganGriffith3,JinpingZhao4,YongbiaoZhang5,DaoxinXie6,JianbinYan8,91MOEKeyLaboratoryofBioinformatics,Tsinghua-PekingJointCenterf ...
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Rapid and specific isolation of intact mitochondria from Arabidopsis leaves
LilanLuo1,1,YajunHe2,3,1,QianXu4,5,1,WenhuiLyu6,JijunYan7,PeiyongXin8,DahanZhang9,10,JinfangChu11,JiayangLi12,13,HongYu141StateKeyLaboratoryofPlantGen ...
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PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis
AihuaMaoa,MingmingZhanga,JieLiua,YuCaoa,QiangWanga,baStateKeyLaboratoryofMembraneBiology,InstituteofZoology,UniversityofChineseAcademyofSciences,Chine ...
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Glycolysis regulates gene expression by promoting the crosstalk between H3K4 trimethylation and H3K1
YinshengWua,#,ShihaoZhanga,#,XuanyunjingGonga,#,QiYua,#,YuanZhanga,MingdanLuoa,XianhuaZhanga,JerryL.Workmanb,XilanYua,ShanshanLiaaStateKeyLaboratoryof ...
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MpbR, an essential transcriptional factor for Mycobacterium tuberculosis survival in the host, modul
YugangLia,WeihuiLib,ZhiweiXiea,HuiXua,Zheng-GuoHea,baNationalKeyLaboratoryofAgriculturalMicrobiology,CollegeofLifeScienceandTechnology,HuazhongAgricul ...
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Disruptor of telomeric silencing 1-like (DOT1L) is involved in breast cancer metastasis via transcri
YangDuan1,2,XingyanZhang3,LihongYang4,XuDong5,ZhanyeZheng6,YimingCheng7,HaoChen8,BeiLan9,DengwenLi10,JunZhou11,12,ChenghaoXuan131TianjinKeyLaboratoryo ...
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dbEMT 2.0: An updated database for epithelial-mesenchymal transition genes with experimentally verif
MinZhao1,YiningLiu2,ChongZheng3,HongQu41SchoolofScience,andEngineering,UniversityoftheSunshineCoast,MaroochydoreDC,Queensland,4558,Australia2TheSchool ...
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A behavioral paradigm to study the persistence of reward memory extinction in Drosophila
LinglingWang1,#,QiYang1,#,BinyanLu2,LianzhangWang4,YiZhong4,QianLi41Tsinghua-PekingCenterforLifeSciences,MOEKeyLaboratoryofProteinSciences,IDG/McGover ...
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Off-target effects of cytidine base editor and adenine base editor: What can we do?
PupingLianga,b,JinkunWena,b,c,JunjiuHuanga,b,daKeyLaboratoryofReproductiveMedicineofGuangdongProvince,SchoolofLifeSciences,andtheFirstAffiliatedHospit ...
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Advances in detecting and reducing off-target effects generated by CRISPR-mediated genome editing
JinjingLia,b,#,ShunyanHonga,b,#,WanjinChena,b,ErweiZuoc,HuiYangdaDepartmentofNeurologyandInstituteofNeurology,TheFirstAffiliatedHospitalofFujianMedica ...
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Engineering guide RNA to reduce the off-target effects of CRISPR
JingWua,b,HaoYina,b,caDepartmentofPathology,MedicalResearchInstitute,ZhongnanHospitalofWuhanUniversity,Wuhan,430071,ChinabFrontierScienceCenterforImmu ...
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Site-directed RNA editing (SDRE): Off-target effects and their countermeasures
ShaoshuaiMaoa,b,c,YajingLiua,b,c,ShishengHuanga,b,c,XingxuHuanga,TianChia,daSchoolofLifeSciencesandTechnology,ShanghaiTechUniversity,Shanghai,201210,C ...
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Drosophila CTP synthase can form distinct substrate- and product-bound filaments
XianZhoua,#,Chen-JunGuoa,#,Huan-HuanHua,b,c,JialeZhonga,b,c,QianqianSuna,d,DandanLiua,d,ShuangZhoua,b,c,ChiaChunChanga,Ji-LongLiuaaSchoolofLifeScience ...
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Establishment and characterization of a complete set of Triticum durum-Thinopyrum elongatum monosomi
JingWang1,QinghuaShi2,XianruiGuo3,FangpuHan41CenterforAgriculturalResourcesResearch,InstituteofGeneticsandDevelopmentalBiology,ChineseAcademyofScience ...
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Acquisition of functional neurons by direct conversion: Switching the developmental clock directly
ShuangquanChenb,#,JuanZhanga,#,DongmingZhanga,#,JianweiJiaoa,c,d,eaInstituteofZoology,ChineseAcademyofSciences,Beijing,100101,ChinabSchoolofPharmaceut ...
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Histone modifications and their regulatory roles in plant development and environmental memory
TingZhaoa,#,ZhenpingZhana,b,#,DanhuaJianga,baStateKeyLaboratoryofPlantGenomics,InstituteofGeneticsandDevelopmentalBiology,TheInnovativeAcademyofSeedDe ...
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RASSF6-TRIM16 axis promotes cell proliferation, migration and invasion in esophageal squamous cell c
LeileiZhenga,#,ZitongZhaoa,#,LuluRongb,LiyanXueb,YongmeiSongaaStateKeyLaboratoryofMolecularOncology,NationalCancerCenter/NationalClinicalResearchCente ...
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Embryonic lineage tracing with Procr-CreER marks balanced hematopoietic stem cell fate during entire
XiaonaZhenga,GuangyuZhanga,YandongGonga,XiaoweiNinga,ZhijieBaia,JianHea,FanZhoub,c,YanliNid,YuLane,BingLiua,d,e,faStateKeyLaboratoryofProteomics,Acade ...
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Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence
LingXu1,2,DandanYu3,4,YuFan5,6,Yi-PingLiu7,Yong-GangYao8,9,10,111KeyLaboratoryofAnimalModelsandHumanDiseaseMechanismsoftheChineseAcademyofSciences&Yun ...
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Rapid breeding of pink-fruited tomato hybrids using the CRISPR/Cas9 system
TianxiaYang1,LeiDeng2,WeiZhao3,4,RuoxiZhang5,HonglingJiang5,ZhibiaoYe7,Chang-BaoLi8,ChuanyouLi9,101KeyLaboratoryofHorticulturalPlantBiology,Ministryof ...
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