Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor rib

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Hongwei Sun1, 1,
Shengyao Zhi1, 1,
Guifang Wu1,
Guanglan Wu1,
Tianqi Cao1,
Hu Hao2,
Zhou Songyang3, 4, 5, 6 ,
Puping Liang7, 8 ,
Junjiu Huang9, 10, 11
1MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China
2Department of Paediatrics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China
3MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China
4Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences, and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China
5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China
6Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA
7MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China
8Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences, and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China
9MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research, SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China
10Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences, and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China
11State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China

More InformationCorresponding author: E-mail address: songyanz@mail.sysu.edu.cn (Zhou Songyang);E-mail address: liangpp5@mail.sysu.edu.cn (Puping Liang);E-mail address: hjunjiu@mail.sysu.edu.cn (Junjiu Huang)
Publish Date:2020-06-25

Abstract

PDF全文下载地址:

http://www.jgenetgenomics.org/article/exportPdf?id=09096bd2-4825-4b71-b45e-4017eda2b07e&language=en

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