张劲松


性别：
男
研究方向：
营养与毒理; 茶与健康

技术职务：
教授

E-mail：
zjs(at)ahau.edu.cn

通讯地址：
合肥市长江西路130号

邮政编码：
230036

工作经历
2009.3至今安徽农业大学茶树生物学与资源利用国家重点实验室教授博导
2002.3—2009.2中国科学技术大学化学与材料科学学院副研究员
2000.3—2002.2InstituteofFoodResearch,UK访问****
1999.8—2000.2中国科学技术大学化学与材料科学学院讲师
1988.9—1999.7合肥经济技术学院测试中心讲师
学习经历
2002.9—2004.7中国科学院固体物理研究所博士
1985.9—1988.7安徽农学院茶业系硕士
1981.9—1985.7安徽农学院茶业系学士
荣誉
全国优秀教师
第三届中国优秀青年科技创业奖
研究兴趣
营养与毒理，侧重茶与硒，论文他引逾2000次，食品功能成分协同研究被BBCNews、TheTimes、TheGuardian、GenomicsandGeneticsWeekly、CancerWeekly等报道，参编美国食品药品监督管理局（FDA）毒理学国家研究中心原主任DanielCasciano等主编的三部毒理学专著，为ChemicalReviews等30余种SCI期刊评议论文。
论文
(43)DongR,WangD,WangX,ZhangK,ChenP,YangCS,ZhangJ# (#, corresponding author) .Epigallocatechin-3-gallateenhanceskeyenzymaticactivitiesofhepaticthioredoxinandglutathionesystemsinselenium-optimalmicebutactivateshepaticNrf2responsesinselenium-deficientmice.RedoxBiol.10:221-232,2016.
(42)ZhangL,ChengQ,ZhangL,WangY,MerrillGF,IlaniT,FassD,ArnérES,ZhangJ#.Serumthioredoxinreductaseishighlyincreasedinmicewithhepatocellularcarcinomaanditsactivityisrestrainedbyseveralmechanisms.FreeRadicBiolMed.99:426-435,2016.
(41)HanM,ZhaoG,WangY,WangD,SunF,NingJ,WanX#,ZhangJ#.Safetyandanti-hyperglycemicefficacyofvariousteatypesinmice.SciRep.6:31703,2016.
(40)WeiY,ChenP,LingT,WangY,DongR,ZhangC,ZhangL,HanM,WangD,WanX,ZhangJ#.Certain(-)-epigallocatechin-3-gallate(EGCG)auto-oxidationproducts(EAOPs)retainthecytotoxicactivitiesofEGCG.FoodChem.204:218-226,2016.
(39)ZhangL,NingM,XuY,WangC,ZhaoG,CaoQ,ZhangJ#.Predictingthecytotoxicpotencyofcigarettesmokebyassessingthethioredoxinreductaseinhibitorycapacityofcigarettesmokeextract.IntJEnvironResPublicHealth.13:348,2016.
(38)YangCS,ZhangJ,ZhangL,HuangJ,WangY.Mechanismsofbodyweightreductionandmetabolicsyndromealleviationbytea.MolNutrFoodRes.60:160-174,2016.
(37)WangD,WeiY,WangT,WanX,YangCS,ReiterRJ,ZhangJ#.Melatoninattenuates(-)-epigallocatehin-3-gallatetriggeredhepatotoxicitywithoutcompromisingitsdownregulationofhepaticgluconeogenicandlipogenicgenesinmice.JPinealRes.59:497-507,2015.
(36)WangD,WangY,WanX,YangCS,ZhangJ#.Greenteapolyphenol(-)-epigallocatechin-3-gallatetriggeredhepatotoxicityinmice:ResponsesofmajorantioxidantenzymesandtheNrf2rescuepathway.ToxicolApplPharmacol.283:65-74,2015.
(35)WangY,ChenP,ZhaoG,SunK,LiD,WanX,ZhangJ#.Inverserelationshipbetweenelementalseleniumnanoparticlesizeandinhibitionofcancercellgrowthinvitroandinvivo.FoodChemToxicol.85:71-77,2015.
(34)WangX,SunK,TanY,WuS,ZhangJ#.Efficacyandsafetyofseleniumnanoparticlesadministeredintraperitoneallyforthepreventionofgrowthofcancercellsintheperitonealcavity.FreeRadicBiolMed.72C:1-10,2014.
(33)ZhangZ,ZhangJ#,XiaoJ#.Selenoproteinsandseleniumstatusinbonephysiologyandpathology.BiochimBiophysActa.1840:3246-3256,2014.
(32)SunK,ErikssonSE,TanY,ZhangL,ArnérES,ZhangJ#.Serumthioredoxinreductaselevelsincreaseinresponsetochemicallyinducedacuteliverinjury.BiochimBiophysActa.1840:2105-2111,2014.
(31)ZhangL,WeiY,ZhangJ#.Novelmechanismsofanticanceractivitiesofgreenteacomponentepigallocatechin-3-gallate.AnticancerAgentsMedChem.14:779-786,2014.
(30)WuS,SunK,WangX,WangD,WanX,ZhangJ#.Protonationofepigallocatechin-3-gallate(EGCG)resultsinmassiveaggregationandreducedoralbioavailabilityofEGCG-dispersedseleniumnanoparticles.JAgricFoodChem.61:7268-7275.2013.
(29)SunK,WuS,WangY,WanX,ThompsonHJ,ZhangJ#.High-dosesodiumselenitetoxicitycannotbepreventedbytheco-administrationofpharmacologicallevelsofepigallocatechin-3-gallatewhichinturnaggravatesthetoxicity.FoodChemToxicol.52:36-41,2013.
(28)HuangJ,ZhangY,ZhouY,ZhangZ,XieZ,ZhangJ,WanX.Greenteapolyphenolsalleviateobesityinbroilerchickensthroughtheregulationoflipid-metabolism-relatedgenesandtranscriptionfactorexpression.JAgricFoodChem.61:8565-8572,2013.
(27)WangY,LuH,WangD,LiS,SunK,WanX,TaylorEW,ZhangJ#.Inhibitionofglutathionesynthesiseliminatestheadaptiveresponseofascitichepatoma22cellstonedaplatinthattargetsthioredoxinreductase.ToxicolApplPharmacol.265:342-350,2012.
(26)WangD,TaylorEW,WangY,WanX,ZhangJ#.Encapsulatednanoepigallocatechin-3-gallateandelementalseleniumnanoparticlesasparadigmsfornanochemoprevention.IntJNanomedicine.7:1711-1721,2012.
(25)LiJ,SunK,NiL,WangX,WangD,ZhangJ#.Sodiumselenosulfateataninnocuousdosemarkedlypreventscisplatin-inducedgastrointestinaltoxicity.ToxicolApplPharmacol.258:376-383,2012.
(24)ZhangJ#,TaylorEW,WanX,PengD#.Impactofheattreatmentonsize,structure,andbioactivityofelementalseleniumnanoparticles.IntJNanomedicine.7:815-825,2012.
(23)LuY,ZhangJ,WanX,LongM,LiD,LeiP,ZhangZ.Intestinaltransportofpuretheanineandtheanineingreenteaextract:Greenteacomponentsinhibittheanineabsorptionandpromotetheanineexcretion.FoodChem.125:277-280,2011.
(22)LiS,ZhangJ#,LiJ,ChenD,MatteucciM,CurdJ,DuanJ.InhibitionofboththioredoxinreductaseandglutathionereductasemaycontributetotheanticancermechanismofTH-302.BiolTraceElemRes.136:294-301,2010.
(21)WangX,ZhangJ#,XuT.Cyclophosphamide-evokedheartfailureinvolvespronouncedco-suppressionofcytoplasmicthioredoxinreductaseactivityandnon-proteinfreethiollevel.EurJHeartFailure.11:154-162,2009.
(20)ZhangJ#,WangX,XuT.Elementalseleniumatnanosize(Nano-Se)asapotentialchemopreventiveagentwithreducedriskofseleniumtoxicity:comparisonwithse-methylselenocysteineinmice.ToxicolSci.101:22-31,2008.
(19)ZhangJ#,PengD,LuH,LiuQ.Attenuatingthetoxicityofcisplatinbyusingselenosulfatewithreducedriskofseleniumtoxicityascomparedwithselenite.ToxicolApplPharmacol.226:251-259,2008.
(18)ZhangJ#,WangX,LuH.Amifostineincreasescurerateofcisplatinonasciteshepatoma22viaselectivelyprotectingrenalthioredoxinreductase.CancerLett.260:127-136,2008.
(17)WangX,ZhangJ#,XuT.Thioredoxinreductaseinactivationasapivotalmechanismofifosfamideincancertherapy.EurJPharmacol.579:66-73,2008.
(16)ZhangJ#,WangH,PengD,TaylorEW.Furtherinsightintotheimpactofsodiumseleniteonselenoenzymes:High-doseseleniteenhanceshepaticthioredoxinreductase1activityasaconsequenceofliverinjury.ToxicolLett.176:223-229,2008.
(15)LiH,ZhangJ,WangT,LuoW,ZhouQ,JiangG.Elementalseleniumparticlesatnanosize(Nano-Se)aremoretoxictoMedaka(Oryziaslatipes)asaconsequenceofhyper-accumulationofselenium:Acomparisonwithsodiumselenite.AquatToxicol89:251-256,2008.
(14)ZhangJ#,LuH,WangX.SodiumselenosulfatesynthesisanddemonstrationofitsinvitrocytotoxicactivityagainstHepG2,Caco2andthreekindsofleukemiacells.BiolTraceElemRes.125:13-21,2008.
(13)WangH,ZhangJ#,YuH.Elementalseleniumatnanosizepossesseslowertoxicitywithoutcompromisingthefundamentaleffectonselenoenzymes:comparisonwithselenomethionineinmice.FreeRadicBiolMed.42:1524-1533,2007.
(12)ZhangJ#,LuH.Ifosfamideinducesacuterenalfailureviainhibitionofthethioredoxinreductaseactivity.FreeRadicBiolMed.43:1574-1583,2007.
(11)WangX,ZhangJ#,XuT.Cyclophosphamideasapotentinhibitoroftumorthioredoxinreductaseinvivo.ToxicolApplPharmacol.218:88-95,2007.
(10)ZhangJ#,WangH,YuH.Thioacetamide-inducedcirrhosisinselenium-adequatemicedisplaysrapidandpersistentabnormityofhepaticselenoenzymeswhicharemutetoseleniumsupplementation.ToxicolApplPharmacol.224:81-88,2007.
(9)PengD,ZhangJ#,LiuQ,TaylorEW.Sizeeffectofelementalseleniumnanoparticles(Nano-Se)atsupranutritionallevelsonseleniumaccumulationandglutathioneS-transferaseactivity.JInorgBiochem.101:1457-1463,2007.
(8)PengD,ZhangJ#,LiuQ.Effectofsodiumselenosulfateonrestoringactivitiesofselenium-dependentenzymesandseleniumretentioncomparedwithsodiumseleniteinvitroandinvivo.BiolTraceElemRes.117:77-88,2007.
(7)ZhangJ#,MaK,WangH.Cyclophosphamidesuppressesthioredoxinreductaseinbladdertissueanditsadaptiveresponseviainductionsofthioredoxinreductaseandglutathioneperoxidase.ChemBiolInteract.162:24-30,2006.
(6)ZhangJ#,WangH,YanX,ZhangL.Comparisonofshort-termtoxicitybetweenNano-Seandseleniteinmice.LifeSci.76:1099-1109,2005.
(5)ZhangJ#,WangH,BaoY,ZhangL.Nanoredelementalseleniumhasnosizeeffectintheinductionofseleno-enzymesinbothculturedcellsandmice.LifeSci.75:237-244,2004.
(4)HuangB,ZhangJco-first,HouJ,ChenC.FreeradicalscavengingefficiencyofNano-Seinvitro.FreeRadic.BiolMed.35:805-813,2003.
(3)ZhangJ,SvehlíkováV,BaoY,HowieAF,BeckettGJ,WilliamsonG.Synergybetweensulforaphaneandseleniumintheinductionofthioredoxinreductase1requiresbothtranscriptionalandtranslationalmodulation.Carcinogenesis.24:497-503,2003.
(2)GaoX,ZhangJ,ZhangL.Hollowsphereseleniumnanoparticles:theirin-vitroantihydroxylradicaleffect.AdvMater.14:290-293,2002.
(1)ZhangJ,GaoX,ZhangL,BaoY.Biologicaleffectsofananoredelementalselenium.Biofactors.15:27-38,2001.
专著章节
(3)ZhangL,WuS,WangD,WanX,ZhangJ#.Epigallocatechin-3-gallate(EGCG)inoronnanoparticles:EnhancedstabilityandbioavailabilityofEGCGencapsulatedinnanoparticlesortargeteddeliveryofgoldnanoparticlescoatedwithEGCG.In:SahuSC,CascianoD(eds)HandbookofNanotoxicology,NanomedicineandStemCellUseinToxicology.JohnWiley&Sons,pp131-144,2014.
(2)ZhangJ#,SpallholzJ.Toxicityofseleniumcompoundsandnano-seleniumparticles.In:CascianoD,SahuSC(eds)HandbookofSystemsToxicology.JohnWiley&Sons.pp787-802,2011.
(1)ZhangJ#.Biologicalpropertiesofredelementalseleniumatnanosize(Nano-Se)invitroandinvivo.In:SahuSC,CascianoD(eds)Nanotoxicity:FromInVivoandInVitroModeltoHealthRisks.JohnWiley&Sons.pp97-114,2009.
专利
ZhangJ.Useofsodiumselenosulfateforsupplementingseleniumandenhancingthetherapeuticefficacyofchemotherapyagents,andarapidprocessforpreparingsodiumselenosulfate.US8,480,995B2,2013.