夏恩华
(Enhua Xia)
性别：
男
单位：
茶与食品科技学院
专业名称：
茶学
研究方向：
茶树基因组学与生物信息学
技术职务：
特任教授
E-mail：
xiaenhuagmail.com
实验室主页：
tealab.ahau.edu.cn
通讯地址：
安徽省合肥市长江西路130号
邮政编码：
230036
夏恩华，男，汉族，1988年1月生，理学博士，教授，硕导。2017年7月毕业于中国科学院大学生物化学与分子生物学专业，获理学博士学位；同年9月进入安徽农业大学茶树生物学与资源利用国家重点实验室工作。主要从事茶树基因组学与核心种质资源发掘利用等研究。目前主持国家自然科学基金青年项目、安徽省自然科学基金面上项目和安徽农业大学高层次人才引进项目。近5年，在PNAS (3)、Molecular Plant (4)、Plant Physiology、The Plant Journal、Plant Biotechnology Journal等经典期刊发表SCI论文40余篇，引用达数千余次(截止2020年5月)，多篇论文入选Web of Science“高被引论文” (学术领域中最优秀的1%) 和“热点论文” (学术领域中最优秀的0.1%)。
教育经历：
2014/09-2017/07，中国科学院大学，生物化学与分子生物学，理学博士
2011/09-2014/07，中国科学院大学，生物化学与分子生物学，理学硕士
2006/09-2011/07，哈尔滨医科大学，五年制生物信息学，理学学士
教学情况：
讲授本科生课程《植物生物技术导论》，研究生课程《茶学研究进展》
科研情况：
1. 主要研究方向
1）茶树比较功能基因组学和群体遗传学研究：茶树重要农艺性状形成、重要天然产物生物合成的基因组学基础和新基因发掘；茶树起源及重要驯化相关基因的克隆、功能鉴定与利用
2）茶树及其近缘植物系统发育基因组学和进化生物学研究：山茶属植物系统发育关系构建；近缘植物基因组之间的渐渗及进化后果；山茶属植物代谢组动态变化及其分子机制
3）生物信息学、分子进化与系统生物学：茶树转座子变异、进化及其对基因表达与功能的影响；茶树基因重复（包括全基因组重复）后重复基因的命运、进化机制及其对茶叶品质和茶树全球生态适应性的影响
2. 主持科研项目
1）国家自然科学基金青年项目，2019/01-2021/12，执行中
2）安徽农业大学高层次人才引进启动项目，2017/09-2022/09，执行中
3）安徽自然科学基金面上项目，2019/07-2021/07，执行中
获奖情况：
中国科学院朱李月华优秀博士生奖（2015）
研究生国家奖学金（2016）
中国科学院院长优秀奖（2017）
论文论著：
注：#共同第一；*通讯作者
代表论文：
1)En-Hua Xia#, Wei Tong#, Yan Hou#, Yan-Lin An#, Lin-Bo Chen, Qiong Wu, Yun-Long Liu, Jie Yu, Fang-Dong Li, Ruo-Pei Li, Peng-Hui Li, Hui-Juan Zhao, Ruo-Heng Ge, Jin Huang, Ali Inayat Mallano, Yan-Rui Zhang, Sheng-Rui Liu, Weiwei Deng, Chuankui Song, Zhaoliang Zhang, Jian Zhao, Shu Wei, Zhengzhu Zhang, Tao Xia, Chao-Ling Wei*, Xiao-Chun Wan*. (2020).The reference genome of tea plant and resequencing of 81 diverse accessions provide insights into genome evolution and adaptation of tea plants.Molecular Plant13(7): 1013-1026. [PubMed]
2)En-Hua Xia#, Hai-Bin Zhang#, Jun Sheng#, Kui Li#, Qun-Jie Zhang#, Changhoon Kim, Yun Zhang, Yuan Liu, Ting Zhu, Wei Li, Hui Huang, Yan Tong, Hong Nan, Cong Shi, Chao Shi, Jian-Jun Jiang, Shu-Yan Mao, Jun-Ying Jiao, Dan Zhang, Yuan Zhao, You-Jie Zhao, Li-Ping Zhang, Ben-Ying Liu, Yue Yu, Sheng-Fu Zhao, De-Jiang Ni, Evan E. Eichler, Li-Zhi Gao* (2017). The tea tree genome provides new insights into tea flavor and independent evolution of caffeine biosynthesis. Molecular Plant 10(6): 866-877. [PubMed]
3)Wei Tong#,Ruo-Pei Li#, Jin Huang, Hui-Juan Zhao, Ruoheng Ge, Qiong Wu, Inayat Mallano Ali, Yanli Wang, Fangdong Li, Weiwei Deng, Yeyun Li, andEn-Hua Xia*(2021). Divergent DNA methylation contributes to duplicated gene evolution and chilling response in tea plants. The Plant Journal 10(6): 866-877. [PubMed]
4)En-Hua Xia#, Fang-Dong Li#, Wei Tong#, Peng-Hui Li, Qiong Wu, Hui-Juan Zhao, Ruo-Heng Ge, Ruo-Pei Li, Ye-Yun Li, Zheng-Zhu Zhang, Chao-Ling Wei*, Xiao-Chun Wan* (2019). Tea Plant Information Archive (TPIA): A comprehensive genomics and bioinformatics platform for tea plant.Plant Biotechnology Journal17(10): 1938-1953. [PubMed]
5)En-Hua Xia#, Wei Tong#, Qiong Wu, Shu Wei, Jian Zhao, Zheng-Zhu Zhang, Chao-Ling Wei*, Xiao-Chun Wan* (2020).Tea plant genomics: achievements, challenges and perspectives.Horticulture Research 7: 7doi:10.1038/s41438-019-0225-4. [PubMed]
6) Qun-Jie Zhang#, Ting Zhu#, En-Hua Xia#, Chao Shi#, Yun-Long Liu#, Yun Zhang#, Yuan Liu#, Wen-Kai Jiang, You-Jie Zhao, Shu-Yan Mao, Li-Ping Zhang, Hui Huang, Jun-Ying Jiao, Ping-Zhen Xu, Qiu-Yang Yao, Fan-Chun Zeng, Li-Li Yang, Ju Gao, Da-Yun Tao, Yue-Ju Wang, Jeffrey L Bennetzen*, Li-Zhi Gao*. (2014). Rapid diversification of five Oryza AA genomes associated with rice adaptation. PNAS111: E4954-E4962. [PubMed]
7) Dan Zhang#, Wei Li#, En-Hua Xia#, Qun-Jie Zhang#, Yuan Liu, Yun Zhang, Yan Tong, Yuan Zhao, Yong-Chao Niu, Jia-Huan Xu, Li-Zhi Gao* (2017). The medicinal herb Panax notoginseng genome provides insights into ginsenoside biosynthesis and genome evolution. Molecular Plant 10(6): 903–907. [PubMed]
8) Chaoling Wei#, Hua Yang#, Songbo Wang#, Jian Zhao#, Chun Liu#, Liping Gao#,Enhua Xia, Ying Lu, Yu-Ling Tai, Guang-Biao She, Jun Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, YiYue, Fangdong Li, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L. Bennetzen*, Shancen Zhao*, and Xiaochun Wan* (2018). Draft genome sequence ofCamellia sinensisvar.sinensisprovides insights into the evolution of the tea genome and tea quality.PNAS115(1): E4151-E4158. [PubMed]
其它论文：
34)Lidiia S. Samarina*, Alexander V. Bobrovskikh, Alexey V. Doroshkov, Lyudmila S. Malyukova, Alexandra O. Matskiv, Ruslan S. Rakhmangulov, Natalia G. Koninskaya, Valentina I. Malyarovskaya, Wei Tong, Enhua Xia, Karina M. Manakhova, Alexey V. Ryndin, Yuriy L. Orlov(2020).Comparative expression analysis of stress-inducible candidate genes in response to cold and drought in tea plant (Camellia sinensis (L.) Kuntze).Frontiers in Geneticsdoi: 10.3389/fgene.2020.611283.[PubMed]
33)Qijuan Gao#, Xiu Jin#, Enhua Xia, Xiangwei Wu, Lichuan Gu, Hanwei Yan, Yingchun Xia, Shaowen Li* (2020).Identification of orphan genes in unbalanced datasets based on ensemble learning.Frontiers in Plant Sciences11: 820.[PubMed]
32)Xiao-Bin Liu, En-Hua Xia, Meng Li, Yang-Yang Cui, Pan-Meng Wang, Jin-Xia Zhang, Bao-Gui Xie, Jian-Ping Xu, Jun-Jie Yan, Jing Li, László G. Nagy, Zhu L. Yang* (2020). Transcriptome data reveal conserved patterns of fruiting body development and response to heat stress in the mushroom-forming fungus Flammulina filiformis. PLoS ONE 15(10): e**.[PubMed]
31)Mengshuang Li, Jing Lu, Ming M. Tao, Meng R. Li, Hua Yang, Enhua Xia, Qi Chen* and Xiaochun Wan* (2020).Genome-wide identification of seven polyamine oxidase genes in Camellia sinensis (L.) and their expression patterns under various abiotic stresses.Frontiers in Plant Sciencesdoi: 10.3389/fpls.2020.544933.[PubMed]
30)Tianyuan Yang, Xin Lu, Yan Wang, Yunxia Xie, Jingzhen Ma, Xunmin Cheng, Enhua Xia, Xiaochun Wan* and Zhaoliang Zhang* (2020).HAK/KUP/KT family potassium transporter genes are involved in potassium deficiency and stress responses in tea plants (Camellia sinensis L.): expression and functional analysis. BMC Genomics 21: 556.[PubMed]
29)Muhammad Zulfiqar Ahmad, Penghui Li, Guangbiao She, Enhua Xia, Vagner A. Benedito, Xiao Chun Wan and Jian Zhao* (2020).Genome-Wide Analysis of Serine Carboxypeptidase-Like Acyltransferase Gene Family for Evolution and Characterization of Enzymes Involved in the Biosynthesis of Galloylated Catechins in the Tea Plant (Camellia sinensis).Frontiers in Plant Sciencesdoi: 10.3389/fpls.2020.00848.[PubMed]
28)Zhe Hu#, Qiuyan Ban#, Jing Hao, Xiangxiang Zhu, Yaohua Cheng, Junlin Mao, Mengling Lin, Enhua Xia*, Yeyun Li* (2020). Genome-wide characterization of the C-repeat binding factor (CBF) gene family involved in the response to abiotic stresses in tea plant (Camellia sinensis). Frontiers in Plant Sciencesdoi: 10.3389/fpls.2020.00921.[PubMed]
27) Wei Li#, Qun-Jie Zhang#, Ting Zhu#, Yan Tong#, Kui Li#, Cong Shi, Yun Zhang, Yun-Long Liu, Jian-Jun Jiang Yuan Liu, En-Hua Xia, Hui Huang, Li-Ping Zhang, Dan Zhang, Chao Shi, Wen-Kai Jiang, You-Jie Zhao Shu-Yan Mao, Jun-ying Jiao, Ping-Zhen Xu, Li-Li Yang, Li-Zhi Gao* (2020).Draft genomes of two outcrossing wild rice, Oryza rufipogon and O. longistaminata, reveal genomic features associated with mating‐system evolution.Plant Direct doi:10.1002/pld3.232.[PubMed]
26)Yajun Liu#, Guifu Zhao#, Xin Li#, Qiang Shen, Qiong Wu, Juhua Zhuang, Xiaoqin Zhang, Enhua Xia, Zhengzhu Zhang, Yumei Qian, Liping Gao*, and Tao Xia* (2020).Comparative analysis of phenolic compound metabolism among tea plants in the section Thea of the genus Camellia.Food Research International doi:10.1016/j.foodres.2020.109276.[PubMed]
25) Tianyuan Yang, Huiping Li, Yuling Tai, Chunxia Dong, Xunmin Cheng, Enhua Xia, Ziping Chen, Fang Li, Xiaochun Wan*, Zhaoliang Zhang* (2020). Transcriptional regulation of amino acid metabolism in response to nitrogen deficiency and nitrogen forms in tea plant root (Camellia sinensis L.). Scientific Reports10, 6868.[PubMed]
24) Junyang Yue#, Ran Wang#, Xiaojing Ma#, Jiayi Liu, Xiaohui Lu, Sambhaji Balaso Thakar, Ning An, Jia Liu, Enhua Xia*, Yongsheng Liu* (2020). Full-length transcriptome sequencing provides insights into the evolution of apocarotenoid biosynthesis in Crocus sativus. Computational and Structural Biotechnology Journal doi: 10.1016/j.csbj.2020.03.022.[PubMed]
23) Wei Li#, Kui Li#, Qun-jie Zhang#, Ting Zhu#, Yun Zhang#, Cong Shi, Yun-long Liu, En-Hua Xia, Jian-jun Jiang, Chao Shi, Li-ping Zhang, Hui Huang, Yan Tong, Yuan Liu, Dan Zhang, Yuan Zhao, Wen-kai Jiang, You-jie Zhao, Shu-yan Mao, Jun-ying Jiao, Ping-zhen Xu, Li-li Yang, Guo-ying Yin, Li-zhi Gao* (2020). Improved hybrid de novo genome assembly and annotation of African wild rice, Oryza longistaminata, from Illumina and PacBio sequencing reads. Plant Genome doi: 10.1002/tpg2.20001.[PubMed]
22) Wei Li#, Kui Li#, Ying Huang#, Cong Shi, Wu-Shu Hu, Yun Zhang, Qun-Jie Zhang, En-Hua Xia, Ge-Ran Hutang, Xun-Ge Zhu, Yun-Long Liu, Yuan Liu, Yan Tong, Ting Zhu, Hui Huang, Dan Zhang, Yuan Zhao, Wen-Kai Jiang, Jie Yuan, Yong-Chao Niu, Chen-Wen Gao, Li-Zhi Gao* (2020). SMRT sequencing of the Oryza rufipogon genome reveals the genomic basis of rice adaptation. Communications Biology3, 167.[PubMed]
21) Fang-Dong Li#, Wei Tong#, En-Hua Xia*, Chao-Ling Wei* (2019).Optimized sequencing depth and de novo assembler for deeply reconstructing the transcriptome of the tea plant, an economically important plant species.BMC Bioinformatics 20: 553.[PubMed]
20) Jun-Yan Zhu#, Ya-Xian He#, Xiao-Mei Yan#, Lu Liu, Rui Guo, Xiao-Bo Xia, Dao-Jie Cheng, Xiao-Zeng Mi, Lidiia Samarina, Sheng-Rui Liu, En-Hua Xia, Chaoling Wei* (2019).Duplication and transcriptional divergence of three Kunitz protease inhibitor genes that modulate insect and pathogen defenses in tea plant (Camellia sinensis).Horticulture Research 6: 126.[PubMed]
19)En-Hua Xia#, Fang-Dong Li#, Wei Tong, Hua Yang, Song-Bo Wang, Jian Zhao, Chun Liu, Liping Gao, Yuling Tai, Guangbiao She, Jun Sun, Haisheng Cao, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, Yi Yue, Qiong Wu, Ruoheng Ge, Huijuan Zhao, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Shancen Zhao, Jeffrey L Bennetzen, Chaoling Wei*, Xiaochun Wan* (2019).The tea plant reference genome and improved gene annotation using long-read and paired-end sequencing data(2019).Scientific Data6: 122. （提升茶树基因组基因注释质量）[PubMed]
18)Qi-Juan Gao, Han-Wei Yan, En-Hua Xia, Shi-Hua Zhang, Shao-Wen Li (2019).TOGD: A Database of Orphan Genes in Triticum aestivum.International Journal of Agriculture and Biology 22(5):961-966.[PubMed]
17)Zhen-Hua Guo#, Peng-Fei Ma#, Guo-Qian Yang#, Jin-Yong Hu#, Yun-Long Liu#, En-Hua Xia, Mi-Cai Zhong, Lei Zhao, Gui-Ling Sun, Yu-Xing Xu, You-Jie Zhao, Yi-Chi Zhang, Yu-Xiao Zhang, Xue-Mei Zhang, Meng-Yuan Zhou, Ying Guo, Cen Guo, Jing-Xia Liu, Xia-Ying Ye, Yun-Mei Chen, Yang Yang, Bin Han, Choun-Sea Lin*, Ying Lu*, De-Zhu Li* (2019). Genome sequences provide insights into the reticulate origin and unique traits of woody bamboos. Molecular Plant doi: 10.1016/j.molp.2019.05.009.[PubMed]
16) Yuling Tai#, Chun Liu#, Shuwei Yu, Hua Yang, Jiameng Sun, Chunxiao Guo, Bei Huang, Zhaoye Liu, Yi Yuan, Enhua Xia, Chaoling Wei*, Xiaochun Wan* (2018). Gene co-expression network analysis reveals coordinated regulation of three characteristic secondary biosynthetic pathways in tea plant (Camellia sinensis). BMC Genomics19: 616. [PubMed]
15) Hui Huang, Qiu-Yang Yao, En-Hua Xia, Li-Zhi Gao* (2018). Metabolomics and Transcriptomics Analyses Reveal Nitrogen Influences on the Accumulation of Flavonoids and Amino Acids in Young Shoots of Tea Plant (Camellia sinensis L.) Associated with Tea Flavor.Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.8b01995.[PubMed]
14)En-Hua Xia#, Da-Rong Yang#, Jian-Jun Jiang#, Qun-Jie Zhang, Yuan Liu, Yun-Long Liu, Yun Zhang, Hai-Bin Zhang, Cong Shi, Yan Tong, Changhoon Kim, Hua Chen, Yan-Qiong Peng, Yue Yu, Evan E. Eichler, Li-Zhi Gao* (2017). The caterpillar fungus,Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity.Scientific Reports7: 1806.（揭示冬虫夏草菌真菌致病性及高海拔生态适应性的遗传基础）[PubMed]
13) Hui Huang#,En-Hua Xia#, Hai-Bin Zhang, Qiu-Yang Yao, Li-Zhi Gao* (2017). De novo transcriptome sequencing ofCamellia sasanquaand the analysis of major candidate genes related to floral traits.Plant Physiology and Biochemistry120: 103-111.[PubMed]
12) Xi-Hui Du, Qi Zhao,En-Hua Xia, Li-Zhi Gao, Franck Richard, Zhu L. Yang* (2017). Mixed-reproductive strategies, competitive mating-type distribution and life cycle of fourteen black morel species.Scientific Reports7: 1493.[PubMed]
11)En-Hua Xia#, Qiu-Yang Yao#, Hai-Bin Zhang, Jian-Jun Jiang, Li-Ping Zhang, Li-Zhi Gao* (2016). CandiSSR: An efficient pipeline used for identifying candidate polymorphic SSRs based on multiple assembled sequences.Frontiers in Plant Science6: 1171. doi:10.3389/fpls.2015.01171.（整合组学大数据开发了一套生物信息学软件，用于大规模鉴定茶树基因组多态性SSR；软件自动化程度、运行效率和通量高，实验证实准确度高达90%以上）[PubMed]
10) Chao Shi#, Shuo Wang#,En-Hua Xia#, Jian-Jun Jiang, Fan-Chun Zeng, Li-Zhi Gao* (2016). Full transcription of the chloroplast genome in photosynthetic eukaryotes.Scientific Reports6: 30135.（发现植物叶绿体基因组全转录的新机制，并提出一种新的叶绿体基因组双向启动子多重转录模型来解释该现象）[PubMed]
9) Qiu-Yang Yao#, Hui Huang#, Yan Tong,En-Hua Xia, Li-Zhi Gao* (2016). Transcriptome analysis identifies candidate genes related to triacylglycerol and pigment biosynthesis and photoperiodic flowering in the ornamental and Oil-Producing plant,Camellia reticulata(Theaceae).Frontiers in Plant Science7: 163.[PubMed]
8) Jie Zhang, Yuan Liu,En-Hua Xia, Qiu-Yang Yao, Xiang-Dong Liu, Li-Zhi Gao* (2015). Autotetraploid rice methylome analysis reveals methylation variation of transposable elements and their effects on gene expression.PNAS112(50): E7022-E7029.（阐明DNA转座子甲基化介导的周边蛋白编码基因表达变化是水稻多倍体应对基因组加倍冲击的有效方式）[PubMed]
7) Hai-Bin Zhang#,En-Hua Xia#, Hui Huang, Jian-Jun Jiang, Li-Zhi Gao* (2015). De novo transcriptome assembly of the wild relative of tea tree (Camellia taliensis) and comparative analysis with tea transcriptome identified putative genes associated with tea quality and stress response.BMC Genomics16: 298.[PubMed]
6) Qiu-Yang Yao,En-Hua Xia, Fei-Hu Liu, Li-Zhi Gao* (2015). Genome-wide identification and comparative expression analysis reveal a rapid expansion and functional divergence of duplicated genes in the WRKY gene family of cabbage,Brassica oleraceavar.capitata.Gene557(1): 35-42.[PubMed]
5) Ning Wang,En-Hua Xia, Li-Zhi Gao* (2015). Genome-wide analysis of WRKY family of transcription factors in common bean,Phaseolus vulgaris: Chromosomal localization, structure, evolution and expression divergence.Plant Gene5:22-30.[PubMed]
4)En-Hua Xia#, Jian-Jun Jiang#, Hui Huang, Liping Zhang, Haibin Zhang, Lizhi Gao* (2014). Transcriptome analysis of the Oil-rich tea plant,Camellia oleifera, reveals candidate genes related to lipid metabolism.PLoS ONE9(8):e104150.（茶油享有“东方橄榄油”之美誉的转录组学证据）[PubMed]
3) Jian-Jun Jiang#,En-Hua Xia#, Cheng-Wen Gao, Li-Zhi Gao* (2014). The complete mitochondrial genome of western painted turtle,Chrysemys picta bellii(Chrysemys, Emydidae).Mitochondrial DNA Part A27(2): 787-788.[PubMed]
2) Chao Shi#, Yuan Liu#, Hui Huang,En-Hua Xia, Hai-Bin Zhang, Li-Zhi Gao* (2013). Contradiction between plastid gene transcription and function due to complex posttranscriptional splicing: An exemplary study ofycf15function and evolution in angiosperm.PLoS ONE8(3): e59620.[PubMed]
1) Wen-Kai Jiang, Yun-Long Liu,En-Hua Xia, Li-Zhi Gao (2013). Prevalent role of gene features in determining evolutionary fates of WGD duplicated genes in flowering plants.Plant Physiology161(4): 1844-1861.（禾本科作物重复基因的进化命运）[PubMed]
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