导师姓名： 李令杰 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市黄浦区重庆南路280号，上海交大医学院西院五号楼509室lingjie@shsmu.edu.cn86--776766
邮编： 200020 邮箱地址： ljli@stanford.edu

研究方向 (点击浏览详细信息)
主要方向：干细胞分化发育与疾病的表观遗传调控
A. 上皮组织发育中的表观遗传调控规律
B. 早期外胚层细胞分化、发育的调控机制
C. 成体皮肤组织稳态平衡及相关疾病的调控
D. 发展基于干细胞的再生医学技术及应用研究

社会任职

科研项目

学术论文 作者论文标题期刊名出版年卷期页码
Lingjie Li, Yong Wang, Jessica L Torkelson, Gautam Shankar, Jillian M Pattison, Hanson H Zhen, Fengqin Fang, Zhana Duren, Jingxue Xin, Sadhana Gaddam, Sandra P Melo, Samantha N Piekos, Jiang Li, Eric J Liaw, Lang Chen, Rui Li, Marius Wernig, Wing H Wong, Howard Y Chang, Anthony E Oro TFAP2C-and p63-dependent networks sequentially rearrange chromatin landscapes to drive human epidermal lineage commitment Cell Stem Cell 2019 24 (2), 271-284. e8
Jingwen Fang, Qing Ma, Ci Chu, Beibei Huang, Lingjie Li, Pengfei Cai, Pedro J Batista, Karen Erisse Martin Tolentino, Jin Xu, Rui Li, Pengcheng Du, Kun Qu, Howard Y Chang PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications Genome Biology 2019 20 (1), 1-21
Jillian M Pattison, Sandra P Melo, Samantha N Piekos, Jessica L Torkelson, Elizaveta Bashkirova, Maxwell R Mumbach, Charlotte Rajasingh, Hanson Hui Zhen, Lingjie Li, Eric Liaw, Daniel Alber, Adam J Rubin, Gautam Shankar, Xiaomin Bao, Howard Y Chang, Paul A Khavari, Anthony E Oro Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment Nature Genetics 2018 50 (12), 1658-1665
Lingjie Li, Jill A Helms, Howard Y Chang Comment on " Hotair Is Dispensable for Mouse Development" PLoS Genet. 2016 12 (12), e**
Vittorio Sebastiano, Hanson Hui Zhen, Bahareh Haddad, Elizaveta Bashkirova, Sandra P Melo, Pei Wang, Thomas L Leung, Zurab Siprashvili, Andrea Tichy, Jiang Li, Mohammed Ameen, John Hawkins, Susie Lee, Lingjie Li, Aaron Schwertschkow, Gerhard Bauer, Leszek Lisowski, Mark A Kay, Seung K Kim, Alfred T Lane, Marius Wernig, Anthony E Oro Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa Science Translational Medicine 2014 6 (264), 264ra163-264ra163
Pedro J Batista, Benoit Molinie, Jinkai Wang, Kun Qu, Jiajing Zhang, Lingjie Li, Donna M Bouley, Ernesto Lujan, Bahareh Haddad, Kaveh Daneshvar, Ava C Carter, Ryan A Flynn, Chan Zhou, Kok-Seong Lim, Peter Dedon, Marius Wernig, Alan C Mullen, Yi Xing, Cosmas C Giallourakis, Howard Y Chang m6A RNA modification controls cell fate transition in mammalian embryonic stem cells Cell Stem Cell 2014 15 (6), 707-719
Lingjie Li, Howard Y Chang Physiological roles of long noncoding RNAs: insight from knockout mice Trends in Cell Biology 2014 24 (10), 594-602
Hongyao Yu, Ke He, Lingjie Li, Lei Sun, Fan Tang, Ruizhen Li, Wen Ning, Ying Jin Deletion of STK40 protein in mice causes respiratory failure and death at birth Journal of Biological Chemistry 2013 288 (8), 5342-5352
Lingjie Li, Bo Liu, Orly L Wapinski, Miao-Chih Tsai, Kun Qu, Jiajing Zhang, Jeff C Carlson, Meihong Lin, Fengqin Fang, Rajnish A Gupta, Jill A Helms, Howard Y Chang Targeted disruption of Hotair leads to homeotic transformation and gene derepression Cell Reports 2013 5 (1), 3-12
Lingjie Li （共同第一作者）, Lei Sun, Furong Gao, Jing Jiang, Ying Yang, Chunliang Li, Junjie Gu, Zhe Wei, Acong Yang, Rui Lu, Yu Ma, Fan Tang, Sung Won Kwon, Yingming Zhao, Jinsong Li, Ying Jin Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation Proceedings of the National Academy of Sciences 2010 107 (4), 1402-1407
李令杰, 金颖 调控胚胎干细胞自我更新的关键转录因子研究进展 Chinese Bulletin of Life Sciences 2009 21 (5) 631-638
王治, 戴秋艳, 吴亚兰, 徐国彤, 李令杰, 孙宝贵 p α-MHC/EGFP 小鼠胚胎干细胞株的构建及其向心肌细胞分化的观察 上海交通大學學報 (醫學版) 2008 28 (8), 957-961