导师姓名： 张明亮 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： mingliang.zhang@shsmu.edu.cn
邮编： 200025 邮箱地址： mingliang.zhang@shsmu.edu.cn

研究方向 (点击浏览详细信息)
干细胞与神经发育/退行性疾病

社会任职
中国医师协会眼科分会（学组）委员
中国细胞生物学会青年工作委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
6 上海市“科技创新”行动计划 上海市科委 2019-11~2022-11 79万元 课题负责人
5 国家自然科学基金面上项目 国家自然科学基金委员会 2018-01~2021-12 65万元 课题负责人
2 上海市高层次人才计划 上海市教委 2018-01~2020-12 100万元 课题负责人
1 上海市高层次人才计划 上海市科委 2017-06~2019-05 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhou-Li Cheng, Meng-Li Zhang, Huai-Peng Lin, Chao Gao, Jun-Bin Song, Zhi-Hong Zheng, Lin-Peng Li, Ya-Nan Zhang, Xiao-Qi Shen, Hao Zhang, Zheng-hui Huang, Wu-qiang Zhan, Cheng Zhang, Yi-Ping Sun, Lu-Bing Jiang, Lei Sun, Ze Li, Yanhui Xu, Chen Yang, Yuan-Long Ge, Yong Zhao, Xing-Guo Liu, Hui Yang, Peng-Yuan Liu, Xing Guo, Kun-Liang Guan, Yue Xiong, Mingliang Zhang* （通讯作者）, and Dan Ye* The Zscan4-Tet2 transcription nexus regulates metabolic rewiring and enhances proteostasis to promote reprogramming Cell Reports 2020 32, 107877, July 14, 2020
Pingxin Sun,Guanyu Zhang,Xiaohui Su,Caixia Jin,Bing Yu,Xinlu Yu,Zhuman Lv,Haoxin Ma,Mingliang Zhang,Wanguo Wei,and Wenlin Li Maintenance of Primary Hepatocyte Functions In Vitro by Inhibiting Mechanical Tension-Induced YAP Activation Cell Reports 2019 29(10):3212-3222.e4
Chang Liu#, Xu Hu#, Yawen Li, Wenjie Lu, Wenlin Li, Nan Cao, Saiyong Zhu, Jinke Cheng, Sheng Ding*, and Mingliang Zhang#* （通讯作者） Conversion of Mouse Fibroblasts into Oligodendrocyte Progenitor Like Cells through a Chemical Approach Journal of Molecular Cell Biology 2018 11(6):489-495
Zhu Saiyong, Russ Holger A., Wang Xiaojing, Zhang Mingliang, Ma Tianhua, Xu Tao, Tang Shibing, Hebrok Matthias, and Ding Sheng Human pancreatic beta-like cells converted from fibroblasts Nature Communications 2016 7:10080
Xie Fei, Gong Kerui, Li Ke, Zhang Mingliang, Chang Judy C., Jiang Shizhong, Ye Lin, Wang Jiaming, Tan Yuting, and Kan Yuet-Wai Reversible immortalization enables seamless transdifferentiation of primary fibroblasts into other lineage cells Stem Cells & Development 2016 25 (16):1243-1248
Li Ke, Kong Yan, Zhang Mingliang, Xie Fei, Liu Peng, Xu Shaohua Differentiation of pluripotent stem cells for regenerative medicine Biochem. Biophys. Res. Commun. 2016 471(1):1-4
Zhang Mingliang, Lin Yuan-Hung, Sun Yujiao Jennifer, Zhu Saiyong, Zheng Jiashun, Liu Kai, Cao Nan, Li Ke, Huang Yadong, and Ding Sheng Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation Cell Stem Cell 2016 18 (5):653-667
Cao Nan, Huang Yu, Zheng Jiashun, Spencer C. Ian, Zhang Yu, Fu Ji-Dong, Nei Baoming, Xie Min, Zhang Mingliang, Wang Haixia, Ma Tianhua, Xu Tao, Shi Guilai, Srivastava Deepak and Ding Sheng Conversion of Human Fibroblasts into Functional Cardiomyocytes by Small Molecules Science 2016 352 (6290):1216-1220
Zhang Mingliang#, Li Ke#, Xie Min, and Ding Sheng Chemical Approaches to Controlling Cell Fate Principles of Developmental Genetics, 2nd Edition 2014 59-76
Zhu Saiyong, Ambasudhan Rajesh, Sun Woong, Kim Hyun Jung, Talantova Maria, Wang Xiaojing, Zhang Mingliang, Zhang Yu, Laurent Timothy, Parker James, Kim Han-Seop, Zaremba Jeffrey D, Saleem Sofiyan, Sanz-Blasco Sara, Masliah Eliezer, McKercher Scott R, Cho Yee Sook, Lipton Stuart A, Kim Janghwan and Ding Sheng. Small Molecules Enable Oct4-Mediated Direct Reprogramming into Expandable Human Neural Stem Cells Cell Research 2014 24 (1):126-129
Xu Tao#, Zhang Mingliang# （共同第一作者）, Laurent Timothy, Xie Min, and Ding Sheng Concise review: Chemical Approaches for Modulating Lineage-Specific Stem Cells and Progenitors Stem Cells Translational Medicine 2013 2 (5): 355-361
Tong Xiajing, Li Qianjin, DuanYimin, Liu Ningning, Zhang Mingliang, and Zhou Jinqiu Est1 protects telomeres and inhibits subtelomeric Y’-element recombination Molecular & Cellular Biology 2011 31(6):1263-1274
Zhang Mingliang#, Tong Xiajing#, Fu Xiaohong, Zhou BO, Wang Jianyong, Liao Xinhua,Li Qianjin, Shen Ning, Ding Jianping and Zhou Jinqiu Yeast telomerase subunit Est1p has guanine-quadruplex promoting activity that is required for telomere elongation Nature Structural & Molecular Biology 2010 17 (2):202-209
Liao Xinhua, Zhang Mingliang, Yang Cuiping, Xu Luxia, Zhou Jinqiu Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast Biochemical Journal 2005 390 (Pt 1):169-176