导师姓名： 刘明刚 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 邮箱：lmg**@126.com电话：地址：上海市黄浦区重庆南路280号西院解剖系
邮编： 200025 邮箱地址： lmg**@126.com

研究方向 (点击浏览详细信息)
慢性感觉障碍的神经生物学机制，突触可塑性的分子机制和病理生理意义

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 前扣带回皮层酸敏感离子通道调节慢性痛及其可塑性改变的机制研究 国家自然科学基金面上项目 2018-01~2021-12 57万元 课题负责人
** 岛叶皮层突触可塑性的非经典离子通道机制 国家自然科学基金青年科学基金 2016-01~2018-12 20万元 课题负责人
QD** 上海市青年****人才计划 上海市教委 2015-01~2017-12 60万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Su XY, Chen M, Yuan Y （通讯作者）, Li Y, Guo SS, Luo HQ, Huang C, Sun W, Li Y, Zhu MX, Liu MG, Hu J, Xu TL. Central processing of itch in the midbrain reward center. Neuron 2019 102:858-872.
Xiong CH, Liu MG, Zhao LX, Chen MW, Tang L, Yan YH, Chen HZ, Qiu Y. M1 muscarinic receptors facilitate hippocampus-dependent cognitive flexibility via modulating GluA2 subunit of AMPA receptors. Neuropharmacology 2019 146:242-251.
Li HS, Su XY （通讯作者）, Song XL, Qi X, Li Y, Wang RQ, Maximyuk O, Krishtal O, Wang T, Fang H, Liao L, Cao H, Zhang YQ, Zhu MX, Liu MG, Xu TL. Protein kinase C lambda mediates acid-sensing ion channel 1a-dependent cortical synaptic plasticity and pain hypersensitivity. J Neurosci 2019 39:5773-5793
Liu MG, Song Q, Zhuo M. Loss of synaptic tagging in the anterior cingulate cortex after tail amputation in adult mice. J Neurosci 2018 38:8060-8070.
Liu MG, Li HS, Li WG, Wu YJ, Deng SN, Huang C, Maximyuk O, Sukach V, Krishtal O, Zhu MX, Xu TL Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms Scientific Reports 2016 6:23350
Li WG, Liu MG （共同第一作者）, Deng S, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F, Zhu MX, Xu TL ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion Nat Commun 2016 7:13770
Song Q*, Liu MG* （共同第一作者）, Zhuo M Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice Mol Pain 2015 11:25
Koga K*, Liu MG* （共同第一作者）, Qiu S, Song Q, O’Den G, Chen T, Zhuo M Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice.、 J Neurosci 2015 35:2033-2043
Liu MG, Zhuo M Loss of long-term depression in the insular cortex after tail amputation in adult mice Mol Pain 2014 10:1
Chen T, Lu JS, Song Q, Liu MG, Koga K, Descalzi G, Li YQ, Zhuo M Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome Neuropsychopharmacology 2014 39:1955-1967
Liu MG, Chen J. Preclinical research on pain comorbidity with affective disorders and cognitive deficits: challenges and perspectives Prog Neurobiol 2014 116:13-32
Liu MG, Zhuo M No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex Mol Brain 2014 7:27
Liu MG, Kang SJ, Shi TY, Koga K, Zhang MM, Collingridge GL, Kaang BK, Zhuo M Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multi-electrode array recordings J Neurophysiol 2013 110:505-521
Liu MG, Koga K, Guo YY, Kang SJ, Collingridge GL, Kaang BK, Zhao MG, Zhuo M Long-term depression of synaptic transmission in the adult mouse insular cortex in vitro Eur J Neurosci 2013 38:3128-3145
Kang SJ*, Liu MG* （共同第一作者）, Shi TY, Zhao MG, Kaang BK, Zhuo M N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice Mol Pain 2013 9:58
Liu MG, Chen XF, He T, Li Z, Chen J Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space Neurosci Bull 2012 28:409-422
Liu MG, Lu D, Wang Y, Chen XF, Li Z, Xu Y, Jin JH, Wang RR, Chen J Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways. Neurosci Lett 2012 507:38-42
Liu MG, Matsuura S, Shinoda M, Honda K, Suzuki I, Shibuta K, Tamagawa T, Katagiri A, Kiyomoto M, Ohara K, Furukawa A, Urata K, Iwata K Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord J Neuroinflamm 2012 9:258
Kang SJ, Liu MG, Chen T, Ko HG, Baek GC, Lee HR, Lee K, Collingridge GL, Kaang BK, Zhuo M Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation J Neurosci 2012 32:11318-11329
Liu MG, Wang RR, Chen XF, Zhang FK, Cui XY, Chen J. Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: Multi-electrode array recordings Brain Res 2011 1382:57-69
Honda K, Noma N, Shinoda M, Miyamoto M, Katagiri A, Kita D, Liu MG, Sessle BJ, Yasuda M, Iwata K Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats Mol Pain 2011 7:75
Wang DD, Li Zhen, Chang Y, Wang RR, Chen XF, Zhao ZY, Cao FL, Jin JH, Liu MG, Chen J Neural circuits and temporal plasticity in primary somatosensory cortex of rat hindlimb representation: revisited by multi-electrode array on brain slices Neurosci Bull 2010 26:175-187
He Y, Liu MG, Gong KR, Chen J Differential effects of long and short train theta burst stimulation on LTP induction in rat anterior cingulate cortex slices: Multi-electrode array recordings Neurosci Bull 2009 25:309-318
Zhao XY*, Liu MG* （共同第一作者）, Yuan DL, Wang Y, He Y, Wang DD, Chen XF, Zhang FK, Li H, He XS, Chen J Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording Mol Pain 2009 5:55
Liu MG, Chen J Role of the hippocampal formation in pain information processing Neurosci Bull 2009 25:237-266
Yan LH, Hou JF, Liu MG, Li MM, Cui XY, Lu ZM, Zhang FK, An YY, Shi L, Chen J Imbalance between excitatory and inhibitory amino acids at spinal level is associated with maintenance of persistent pain-related behaviors Pharmacol Res 2009 59:290-299
Ren LY, Lu ZM, Liu MG, Yu YQ, Li Z, Shang GW, Chen J Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors Neuroscience 2008 153:268-278
Chang Y, Yan LH, Zhang FK, Gong KR, Liu MG, Xiao Y, Xie F, Fu H, Chen J Spatiotemporal characteristics of pain-associated neuronal activities in primary somatosensory cortex induced by peripheral persistent nociception Neurosci Lett 2008 448:134-138
Lu ZM, Xie F, Fu H, Liu MG, Cao FL, Hao J, Chen J Roles of peripheral P2X and P2Y receptors in the development of melittin-induced nociception and hypersensitivity Neurochem Res 2008 33:2085-2091
Hao J*, Liu MG* （共同第一作者）, Yu YQ, Cao FL, Li Z, Lu ZM, Chen J Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia Neuroscience 2008 152:1067-1075
Guo SW*, Liu MG* （共同第一作者）, Long YL*, Ren LY, Lu ZM, Yu HY, Hou JF, Li H, Gao CY, Cui XY, An YY, Li J, Zhao LF, Chen J Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in na?ve and pain-experiencing rats BMC Neurosci 2007 8:53
Cao FL*, Liu MG* （共同第一作者）, Hao J, Li Z, Lu ZM, Chen J Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors Neurosci Lett 2007 427:50-54
Liu MG, Zhang FK, Guo SW, Zhao LF, An YY, Cui XY, Chen J Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex Neurosci Lett 2007 427:39-43
Yu HY, Liu MG, Liu DN, Shang GW, Wang Y, Qi C, Zhang KP, Song ZJ, Chen J Antinociceptive effects of systemic paeoniflorin on bee venom-induced various ‘phenotypes’ of nociception and hypersensitivity Pharmacol Biochem Behav 2007 88:131-140