导师姓名： 侯照远 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号西7号楼110室Email：houzy@sjtu.edu.cn
邮编： 200025 邮箱地址： houzy@sjtu.edu.cn

研究方向 (点击浏览详细信息)
重大疾病发生发展相关基因的表达调控

社会任职
无

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 去泛素化酶USP29促进乳腺癌细胞转移的分子机制 自然基金委面上项目 2019-01~2022-12 60万元 课题负责人
** LIM蛋白AJUBA在脂肪细胞分化中的作用 国家自然科学基金 2017-01~2020-12 62万元 课题负责人
** 硫酰化修饰在Snail诱导的EMT和肿瘤转移中的作用 国家自然科学基金面上项目 2014-01~2017-12 75万元 课题负责人
** 精氨酸甲基化修饰在Snail 诱导的EMT 和肿瘤转移中的作用 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang B, Song L, Cai J, Li L, Xu H, Li M, Wang J, Shi M, Chen H, Jia H, Zhaoyuan Hou （通讯作者） The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation. J Exp Clin Cancer Res. 2019 38(1):205
Hao Jia, Haixia Peng, Zhaoyuan Hou （通讯作者） Ajuba: An emerging signal transducer in oncogenesis (review) Pharmacol Res. 2019 151:104546
Zhang Y, Zou X, Qian W, Weng X, Zhang L, Zhang L, Wang S, Cao X, Ma L, Wei G, Wu Y, Zhaoyuan Hou （通讯作者） Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis Cell Death & Differ 2019 26(3):565-579
Wang Y, Weng X, Wang L, Hao M, Li Y, Hou L, Liang Y, Wu T, Yao M, Lin G, Jiang Y, Fu G, Hou Z （通讯作者）, Meng X, Lu J, Wang J. HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk JCI 2018 128(12):5235-5250
Xu B, Li Q, Chen N, Zhu C, Meng Q, Ayyanathan K, Qian W, Jia H, Wang J, Ni P, Hou Z. （通讯作者） The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells Nucleic Acids Res. 2018 doi: 10.1093/nar/gky1306
Wang XJ, Qiao Y, Xiao MM, Wang L, Chen J, Lv W, Xu L, Li Y, Wang Y, Tan MD, Huang C, Li J, Zhao TC, Zhaoyuan Hou# （通讯作者）, Jing N#, Chin YE# Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. Cell Reports 2017 18(4):933-946
Chao Liu, Jiamin Wang, Xiaoyuan Yuan, Wenli Qian, Bosen Zhang, Minmin Shi, Junjie Xie, Baiyong Shen, Hong Xu, Zhaoyuan Hou# （通讯作者）, Hao Chen# Long Noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression Oncotarget 2016 7(44):71556-71566
Jia Hao, Liwei Song, Qian Cong, Jiamin Wang, Yihong Zhang, Xiuqun Zou, Chenxi Zhang, Y. Eugene Chin, Xuehong Zhang, Zhiguang Li, Kai Zhu, Zhihai Peng, Bing Wang#, Haixia Peng#, Zhaoyuan Hou# （通讯作者） LIM protein AJUBA promotes colorectal cancer development through suppression of JAK1/STAT1/IFIT2 network Oncogene 2016 . doi: 10.1038/onc.2016.418. [Epub ahead of print])
Hongyan Fan, Weibing Dong, Qi Li, Xiuqun Zou, Yihong Zhang, Jiamin Wang, Shengxian Li, Wei Liu, Ying Dong, Haipeng Sun, Zhaoyuan Hou （通讯作者） Ajuba preferentially binds LXRα/RXRγ heterodimer to enhance LXR target gene expression in liver cells. Molecular Endocrinology 2015 29(11):1608-18. doi: 10.1210/me.2015-1046. Epub 2015 Sep 21
Qi Li, Haixia Peng, Hongyan Fan, Xiuqun Zou, Qian Liu, Yihong Zhang, Hong Xu, Yimin Chu, Chuangui Wang, Kasirajan Ayyanathan, Frank J. Rauscher III, Kaili Zhang, Zhaoyuan Hou （通讯作者） The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction Cell Death & Differentiation 2015 2016 Jan;23(1):158-68. doi: 10.1038/cdd.2015.83. Epub 2015 Jun 26.
Du S, Guan Z, Hao L, Song Y, Wang L, Gong L, Liu L, Qi X, Hou Z （通讯作者）, Shao S. Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration PLoS One 2014 9(1):e85804
Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen H, Shen B, Deng X, Zhou A, Chin YE, Rauscher FJ 3rd, Peng C, Zhaoyuan Hou （通讯作者） Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells Cancer Research 2014 74(16):4353-63
Ni P, Xu H, Chen C, Wang J, Liu X, Hu Y, Fan Q, Hou Z （通讯作者）, Lu Y Serum starvation induces DRAM expression in liver cancer cells via histone modifications within its promoter locus PLoS One 2012 7(12):e50502