导师姓名： 夏立 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海市重庆南路280号老红楼302室
邮编： 邮箱地址： lixia@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤蛋白质组学

社会任职
上海交通大学医学院基础医学公共平台质谱实验室主管
东华大学外聘研究生导师
渥太华-上海联合医学院兼职教授

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 高通量识别非经典蛋白激酶-M2型丙酮酸激酶的磷酸化底物并系统阐明其在促肿瘤发生发展中的机制 国家自然科学基金面上项目 2016-01~2019-12 73.6万元 课题负责人
** 抗白血病候选药物腺花素研究 上海市科委科技支撑项目 2013-06~2016-09 50万元 课题负责人
200701 磷酸化蛋白质组学在研究肿瘤细胞凋亡机制中的应用 上海交通大学医学科学研究院-青年教师科研能力培养计划（一类） 2007-12~2009-11 5万元 课题负责人
** 高通量识别蛋白激酶Cδ的磷酸化底物及其在细胞分化和凋亡中的作用研究 国家自然基金青年科学基金项目 2007-01~2009-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ge, M. K.; Zhang, N.; Xia （共同第一作者）, L.; Zhang, C.; Dong, S. S.; Li, Z. M.; Ji, Y.; Zheng, M. H.; Sun, J.; Chen, G. Q.; Shen, S. M., FBXO22 degrades nuclear PTEN to promote tumorigenesis. Nat Commun 2020 11 (1), 1720
Shen, S. M.; Zhang, C.; Ge, M. K.; Dong, S. S.; Xia, L.; He, P.; Zhang, N.; Ji, Y.; Yang, S.; Yu, Y.; Zheng, J. K.; Yu, J. X.; Xia, Q.; Chen, G. Q., PTENalpha and PTENbeta promote carcinogenesis through WDR5 and H3K4 trimethylation. Nat Cell Biol 2019 21 (11), 1436-1448
Wu, J.; Zhang, W.; Xia （共同第一作者）, L.; Feng, L.; Shu, Z.; Zhang, J.; Ye, W.; Zeng, N.; Zhou, A., Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations. Cell Mol Life Sci 2019 76 (19), 3899-3914
Lu Y, Yan JS, Xia L （共同第一作者）, Qin K, Yin QQ, Xu HT, Gao MQ, Qu XN, Sun YT and Chen GQ. 2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia. Haematologica. 2019 104(1):102-112.
Shen SM, Ji Y, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng JK, Liu JL, Yu JX and Chen GQ. Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. 2018 9(1):2392
Xia L, Qin K, Wang XR, Wang XL, Zhou AW, Chen GQ and Lu Y. Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells. Oncotarget. 2017 8(65):109120-109134.
Yan JS, Li YD, Liu SH, Yin QQ, Liu XY, Xia L, and Lu Y. The t(8;21) fusion protein RUNX1-ETO downregulates PKM2 in acute myeloid leukemia cells. Leukemia Lymphoma. 2017 58(8):1985-1988.
Wei W, Liu C, Qin D, Song L, Xia L, Lei H, Yu Y, Wang W, Pu J, Sun H, Wu Y, Xu H and Hao S. Targeting peroxiredoxin I potentiates 1,25-dihydroxyvitamin D3-induced cell differentiation in leukemia cells. Molecular medicine reports. 2016 13(3):2201-2207.
Xia L, Wang XR, Wang XL, Liu SH, Ding XW, Chen GQ and Lu Y. A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells. The Journal of biological chemistry. 2016 291(50):26138-26150.
Wei W, Ma C, Cao Y, Yang L, Huang Z, Qin D, Chen Y, Liu C, Xia L, Wang T, Lei H, Yu Y, Huang M, Tong Y, Xu H, Gao F, et al. Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells. Oncotarget. 2016 7(4):3873-3883.
Huang L, Jin X, Xia L, Wang X, Yu Y, Liu C, Shao D, Fang N and Meng C. Characterization of mitochondrial NADH dehydrogenase 1alpha subcomplex 10 variants in cardiac muscles from normal Wistar rats and spontaneously hypertensive rats: Implications in the pathogenesis of hypertension. Molecular medicine reports. 2016 13(1):961-966.
Zhang M, Li H, He Y, Sun H, Xia L, Wang L, Sun B, Ma L, Zhang G, Li J, Li Y and Xie L. Construction and Deciphering of Human Phosphorylation-Mediated Signaling Transduction Networks. J Proteome Res. 2015 14(7):2745-2757.
Song LL, Tu YY, Xia L （共同第一作者）, Wang WW, Wei W, Ma CM, Wen DH, Lei H, Xu HZ and Wu YL. Targeting catalase but not peroxiredoxins enhances arsenic trioxide-induced apoptosis in k562 cells. PLoS One. 2014 9(8):e104985.
Wen D, Xu Z, Xia L （共同第一作者）, Liu X, Tu Y, Lei H, Wang W, Wang T, Song L, Ma C, Xu H, Zhu W, Chen G and Wu Y. Important role of SUMOylation of Spliceosome factors in prostate cancer cells. J Proteome Res. 2014 13(8):3571-3582.
Xia L, Wang TD, Shen SM, Zhao M, Sun H, He Y, Xie L, Wu ZX, Han SF, Wang LS and Chen GQ. Phosphoproteomics study on the activated PKCdelta-induced cell death. J Proteome Res. 2013 12(10):4280-4301.
Wu ZX, Zhao M, Xia L, Yu Y, Shen SM, Han SF, Li H, Wang TD, Chen GQ and Wang LS. PKCdelta enhances C/EBPalpha degradation via inducing its phosphorylation and cytoplasmic translocation. Biochem Biophys Res Commun. 2013 433(2):220-225.
Wang LS, Xia L （共同第一作者）, Shen SM, Zheng Y, Yu Y and Chen GQ. Dissecting cell death with proteomic scalpels. Proteomics 2012 12(4-5):597-606.
Liu B, Zheng Y, Wang TD, Xu HZ, Xia L, Zhang J, Wu YL, Chen GQ and Wang LS. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. J Proteome Res. 2012 11(3):1773-1781.
Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, et al. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol. 2012 8(5):486-493.
Zhao M, Xia L and Chen GQ. Protein kinase cdelta in apoptosis: a brief overview. Arch Immunol Ther Exp (Warsz). 2012 60(5):361-372.
Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, et al. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol. 2012 14(7):727-737.
Zhao XY, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ and Zhao KW. Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis. 2010 31(8):1367-1375.
Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W and Yuan Y. Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer. 2010 127(8):1795-1803.
Hong Z, Liu J, Xia L, Pan J, Xiao Q, Lu G, Liang L and Chen SD. Identification of glial-cell-line-derived neurotrophic factor-regulated proteins of striatum in mouse model of Parkinson disease. Proteomics Clin Appl. 2009 3(9):1072-1083.
Yue F, Wang LS, Xia L, Wang XL, Feng B, Lu AG, Chen GQ and Zheng MH. Modulated T-complex protein 1 zeta and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics. Proteomics Clin Appl. 2009 3(10):1225-1235.
Meng C, Jin X, Xia L, Shen SM, Wang XL, Cai J, Chen GQ, Wang LS and Fang NY. Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats. J Proteome Res. 2009 8(5):2463-2475.
Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M and Chen GQ. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics. 2009 9(15):3901-3912.
Zhang N, Zhang H, Xia L, Zheng Y, Yu Y, Zhu Y, Chen G and Di W. NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells. Cancer Lett. 2009 278(2):139-144.
Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK and Chen GQ. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. 2009 9(8):2064-2075.
Wang S, Zheng Y, Yu Y, Xia L, Chen GQ, Yang YZ and Wang LS. Phosphorylation of beta-actin by protein kinase C-delta in camptothecin analog-induced leukemic cell apoptosis. Acta Pharmacol Sin. 2008 29(1):135-142.
Jin X, Wang LS, Xia L, Zheng Y, Meng C, Yu Y, Chen GQ and Fang NY. Hyper-phosphorylation of alpha-enolase in hypertrophied left ventricle of spontaneously hypertensive rat. Biochem Biophys Res Commun. 2008 371(4):804-809.
Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, and Chen GQ. Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. Leukemia. 2008 22(2):378-386.
Guo W, Qu F, Xia L, Guo Q, Ying X and Ding Z. Identification and characterization of ERp29 in rat spermatozoa during epididymal transit. Reproduction. 2007 133(3):575-584
Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS and Chen GQ. Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells. J Proteome Res. 2007 6(9):3808-3818.
Zhang L, Wang LS, Xu Y, Xia L, Chen WL, Zheng Y and Chen GQ Comparative proteomic analysis of human leukemic cells with and without inducible expression of leukemogenic AML1-ETO protein. Chin J Physiol. 2006 49(4):182-191
Han YH, Xia L （共同第一作者）, Song LP, Zheng Y, Chen WL, Zhang L, Huang Y, Chen GQ and Wang LS. Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells Proteomics 2006 6(11):3262-74
Jin X, Xia L （共同第一作者）, Wang LS, Shi JZ, Zheng Y, Chen WL, Zhang L, Liu ZG, Chen GQ and Fang NY. Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats. Proteomics 2006 6(6):1948-1956