导师姓名： 何平 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： hpatsh@sjtu.edu.cn
邮编： 200025 邮箱地址： hpatsh@sjtu.edu.cn

研究方向 (点击浏览详细信息)
病原菌与宿主相互作用机制

社会任职
上海市微生物学会临床微生物专委会 秘书兼委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
19ZR** RIP1介导的细胞程序性坏死在钩端螺旋体感染中的作用及机制研究 上海市科委上海市自然基金 2019-07~2022-06 20万元 课题负责人
201706 广谱多价肺炎多糖疫苗及多价肺炎多糖蛋白结合疫苗的研发 横向课题 2017-06~2020-05 50万元 课题负责人
** 清道夫受体SR-A在抗钩端螺旋体天然免疫中作用机制的研究 国家自然基金，面上项目 2015-01~2018-12 72万元 课题负责人
13ZR** 钩端螺旋体与巨噬细胞相互作用的初步研究 上海市科委，自然基金面上项目 2013-07~2016-06 10万元 课题负责人
C010603 钩端螺旋体rel基因致病机理的研究 国家自然基金，面上项目 2010-01~2013-12 30万元 课题负责人
** 钩端螺旋体基因岛毒力相关基因功能的研究 上海交通大学医学院 2009-01~2011-12 3万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jingwen Huang, Huahua Yi, Chunliu Zhao, Yifan Zhang, Liying Zhu, Bing Liu, Ping He （通讯作者）, Min Zhou. Glucagon-like peptide-1 receptor (GLP-1R) signaling ameliorates dysfunctional immunity in COPD patients. Int J Chron Obstruct Pulmon Dis. 2018 13: 3191–3202
Wenxia Zhang, Yan Guo, Jiayin Li, Yiyuan Zhang, Yang Yang, Dong Dong, Demei Zhu, Ping He and Fupin Hu. （通讯作者） In vitro and in vivo Bactericidal Activity of Ceftazidime-avibactam against Carbapenemase–producing Klebsiella Pneumoniae. Antimicrob Resist Infect Control. 2018 7:142
Yunfen Hua, Tingting Luo, Yiqi Yang, Dong Dong, Rui Wang, Yanjun Wang, Mengsha Xu, Xiaokui Guo, Fupin Hu, Ping He. （通讯作者） Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-Resistant Acinetobacter baumannii in Mice. Front. Microbiol 2017 8:2659
Xia B, Sun L, Fan X, Xiao H, Zhu Y, Qin J, Cai C, Zhao W, Chang YF, Zhang Y, Guo X, He P （通讯作者） A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4 Emerg Microbes Infect 2017 6(5):e36
Song Z, Gu FF, Guo XK, Ni YX, He P （通讯作者）, Han LZ Antimicrobial Resistance and Molecular Characterization of Staphylococcus aureus Causing Childhood Pneumonia in Shanghai. Front Microbiol. 2017 8:455
Qiurui Zhang, Huanying Wan, Shaoguang Huang, Yan Zhang, Yanchun Wang, Xiaokui Guo, Ping He （通讯作者）, Min Zhou. Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease Clin Respir J 2016 10(1):22-31
Ran Dong, Liang Xie, Kaishun Zhao, Qiurui Zhang, Min Zhou, Ping He （通讯作者） Cigarette smoke-induced lung inflammation in chronic obstructive pulmonary disease mediated via LTB4/BLT1/SOCS1 pathway International Journal of Chronic Obstructive Pulmonary Disease 2015 22(11):31-41
WANG Ya Lin, QIN Jin Hong, ZHANG Cui Cai, GUO Xiao Kui, JIANG Xiu Gao, HE Ping. （通讯作者） An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall. Biomed Environ Sci 2014 27(1): 56-59
Boyu Liu, Yanchun Wang, Xiaokui Guo, Weinan Zhu, Yan Zhang, Ping He （通讯作者）, Carboxyfluorescein diacetate succinimidyl ester labeling method to study the interaction between Leptospira and macrophages. Journal of Microbiological Methods. 2014 107: 205–213
Wang Y, Zhao S, Han L, Guo X, Chen M, Ni Y, Zhang Y, Cui Z, He P. （通讯作者） Drug resistance and virulence of uropathogenic Escherichia coli from Shanghai, China. J Antibiot (Tokyo). 2014 67(12):799-805
Ping He, Cong Deng, BoYu Liu, LingBing Zeng, Wei Zhao, Yan Zhang, XuCheng Jiang, XiaoKui Guo, JinHong Qin. Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans. FEMS Microbiol Lett 2013 348：133–142.
Zhang Y, Lou XL, Yang HL, Zhang XY, Guo XK, He P and Jiang XC. （通讯作者） Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route. BMC Infect Dis. 2012
Zelin Cui, Wenbin Shen, Zheng Wang, Haotian Zhang, Me Yao, Yanchun Wang, Lingbin Zeng, Yongzhang Zhu, Jinhong Qin, Ping He and Xiaokui Guo. （通讯作者） Complete Genome Sequence of Klebsiella pneumoniae Phage JD001. J Virol. 2012 86(24):13843.
Lin T, Kwak YH, Sammy F, He P, Thundivalappil S, Sun G, Chao W, Warren HS. Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin. J Infect Dis. 2010 202(4):624-32
Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY, Guo XK. Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China. BMC. Microbiol. 2010
Ping He, Yue-Ying Sheng, Yao-Zhou Shi, Xiu-Gao Jiang, Jin-Hong Qin, Zhi-Ming Zhang, Guo-Ping Zhao and Xiao-Kui Guo. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics 2007
Ping He, Xiang-Yan Zhang, Xiao-Kui Guo, Bao-Yu Hu, Xiao-Tian Huang,Yang Yang, and Guo-Ping Zhao. Identification and analysis of Genes Present Specifically in Leptospira interrogens serovar Lai. Acta Biochimica et Biophysica Sinica, 2004 36(12): 832-839