导师姓名： 张慧慧 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： huizha@shsmu.edu.cn上海市黄浦区重庆南路280号上海交通大学医学院西5号楼1004
邮编： 200025 邮箱地址： huizha@shsmu.edu.cn

研究方向 (点击浏览详细信息)
淋巴细胞的发育、功能及治疗性抗体的功能研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 系统性红斑狼疮中自身反应性CD11c+B细胞的分化途径及其调控机制研究 国家自然科学基金面上项目 2021-01~2024-12 58万元 课题负责人
** 谷氧还蛋白2在B细胞发育中的作用与机制 国家自然科学基金青年项目 2017-01~2019-12 20万元 课题负责人
2015 上海市高校****（青年）****计划 上海市教委 2015-03~2018-03 60万元 课题负责人
15ZR** Fc-huCD40L融合蛋白的抗肿瘤活性及其副作用的研究 上海市科委自然科学基金面上项目 2015-01~2018-12 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhao R, Zhang H, Zhang Y, Li D, Huang C, Li F. In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation. Front Immunol. 2020 10;11:1025. doi: 10.3389/fimmu.2020.01025. eCollection 2020.
Li M, Lazorchak A, Ouyang X, Zhang H, Liu H, Arojo O, Yan L, Jin J, Han Y, Qu G, Xu X, Liu X, Zhang W, Wang Q, Liu D, Li F, Su B. Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation Cellular & Molecular Immunology 2019 16(9):757-769.
Xiaobo Liu, Yingjie Zhao, Huan Shi, Yan Zhang, Xueying Yin, Mingdong Liu, Huihui Zhang, Yongning He, Boxun Lu, Tengchuan Jin & Fubin Li. Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumor activities through biophysical flexibility. Nature Communications 2019 4206
Zhang W, Zhang H （共同第一作者）, Liu S, Xia F, Kang Z, Zhang Y, Liu Y, Xiao H, Chen L, Huang C, Shen N, Xu H, Li F. Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus. PNAS 2019 116 (37) 18550-18560.
Zhang H, Du Y, Zhang X, Lu J, and Holmgren A. Glutaredoxin2 Reduces both Thioredoxin2 and Thioredoxin1 and Protects Cells from Apoptosis Induced by Auranofin and 4-Hydroxynonenal. Antioxid. Redox Signal. 2014 21,669-81
Du Y, Zhang H （共同第一作者）, Montano S, Hegestam J, Ekberg N, Holmgren A, Brismar K, and Ungerstedt J. Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes. Acta diabetologica 2014 51,225-32
Du Y, Zhang H （共同第一作者）, Zhang X, Lu J, and Holmgren A. Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by glutaredoxin system. J. Biol. Chem. 2013 288, 32241-7
Du Y, Zhang H, Lu J, and Holmgren A. Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose. J. Biol. Chem. 2012 287, 38210-9
Ungerstedt J, Du Y, Zhang H, Nair D, and Holmgren A. In vivo redox state of human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Free Radic. Biol. Med. 2012 53, 2002-7
Zhang H, and Zhong L. Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status. Eur. J. Pharmacol. 2010 626, 276-82
Zhang H （共同第一作者）, Cao D, Cui W, Ji M, Qian X, and Zhong L. Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate. Free Radic. Biol. Med. 2010 49, 2010-8
Cao D, Zhang Y, Zhang H, Zhong L, and Qian X. Systematic Characterization of the Covalent Interactions between (-)-Epigallocatechin Gallate and Peptides at Physiological Conditions by Mass Spectrometry. Rapid Commun. Mass Spectrom. 2009 23, 1147-57