导师姓名： 赵克温 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： -776403
邮编： 200025 邮箱地址： zkewen@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤微环境（包括低氧、炎症等）对肿瘤发生的分子机制研究
APC/C新功能的探索
肿瘤发生发展的分子机制研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 髓细胞条件性敲除Apc2调控巨噬细胞极化及其在肿瘤发生中的作用研究 国家自然科学基金面上项目 2016-01~2019-12 68.4万元 课题负责人
** Cbx4经SUMO化修饰增强HIF-1alpha转录活性的分子机制与肝癌发生发展 国家自然科学基金重点项目 2015-01~2019-12 320万元 课题参与人
** 利用诱导敲除小鼠模型结合蛋白质组学技术系统识别APC/C的底物和功能相关蛋白及其功能分析 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
11ZR** 乙酰化及非乙酰化KLF5相互作用蛋白的比较识别及其意义 上海市科学技术委员会自然科学基金 2011-04~2013-03 10万元 课题负责人
11ZZ106 乙酰化及非乙酰化KLF5相互作用蛋白的比较识别及其意义 上海市教育委员会科研创新重点项目 2011-01~2013-12 15万元 课题负责人
06QA14030 低氧诱导因子1a1pha相互作用蛋白网络的识别及其在低氧效应中的研究 上海市科委,启明星 2006-10~2008-09 10万元 课题负责人
** 白血病相关蛋白AML1-ETO调控Connexin-43表达的机制及其发病学意义 国家自然基金委,面上项目 2006-01~2008-12 24万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Fu RJ, He W, Wang XB, Li L, Zhao HB, Liu XY, Pang Z, Chen GQ, Huang L, Zhao KW. （通讯作者） DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma. Cell Death & Disease 2017 8(7):e2952.
Jin W, Liao X, Lv Y, Pang Z, Wang Y, Li Q, Liao Y, Ye Q, Chen G, Zhao K （通讯作者）, Huang L MUC1 induces acquired chemoresistance by upregulating ABCB1 in EGFR-dependent manner Cell Death & Disease 2017 8(8):e2980
Zhao XY, Li L, Wang XB, Fu RJ, Lv YP, Jin W, Meng C, Chen GQ, Huang L, Zhao KW. （通讯作者） 1.Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells. PLoS One 2016 11(10):e**
WANG Xiao-Bo,WANG Hao-Yu,YAO Jun-Ji,ZENG Wan-Qin,LIU Hai-Shan,ZHAO Ke-Wen （通讯作者） Roles of HIF-1α on the Expression of KLF5 Journal of Shanghai Jiao Tong University (Medical science) 2016 36(5): 619-625
Zhiwu Dong, Shuang Liang, Jun Hua, Weiyun Jin, Qilin Zhan, Kewen Zhao （通讯作者） Autophagy as a target for hematological malignancy therapy Blood Reviews 2016 30(5): 369-380
Zhao XY, Wang WX, Lu ZL, Huang L, Zhao KW （通讯作者） Construction and characterization of pOZ-KLF5 retroviral plasmid Life Science research 2015 19(2): 124-130
Cheng BK, Yang J, Mao WY, Shi JJ, Jin W, Liao XD, Kuang Y, Zhao KW, Huang L Establishment of Muc1 gene knockout mouse model SCIENTIA SINICA Vitae 2014 44: 143–150
Chen CQ, Yu K, Yan QX, Xing CY, Chen Y, Yan Z, Shi YF, Zhao KW, Gao SM Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases Carcinogenesis 2013 34(7): 1442-9
Zhao XY, Zhao KW （共同第一作者）, Jiang Y, Zhao M, Chen GQ Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells J. Biol. Chem. 2011 286(42): 36808-19
Zhao KW, Sikriwal D, Dong X, Guo P, Sun X, Dong JT Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells Biochem. J. 2011 437(2): 323-33
Guo P, Dong XY, Zhao KW, Sun X, Li Q, Dong JT Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. Int J Cancer 2010 126(1):81-9
Zhao XY, Chen TT, Xia Li, Guo M, Xu Y, Yue F, Chen GQ, Zhao KW （通讯作者） Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells Carcinogenesis 2010 31(8):1367-75
Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ*. . . , 2009. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells Proteomics 2009 9(15): 3901-12
Guo P, Dong XY, Zhang X, Zhao KW, Sun X, Li Q, Dong JT Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification J. Biol. Chem. 2009 284(10):6071-8
Guo P, Dong XY, Zhao K, Sun X, Li Q, Dong JT Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta J. Biol. Chem. 2009 284(41):28243-52
Guo P, Zhao KW, Dong XY, Sun X, Dong JT Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells J. Biol. Chem. 2009 284(27):18184-93
Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ*. . . , 2008. Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid Haematologica 2008 93(10):1480-7
Gao FH, Wang Q, Wu YL, Li X, Zhao KW, Chen GQ c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression Biochem Biophys Res Commun 2007 356(2):505-11
Li X, Xu YB, Wang Q, Lu Y, Zheng Y, Wang YC, Lübbert M, Zhao KW, Chen GQ Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells J. Cell Physiol. 2006 208(3):594-601
Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells Oncogene 2006 25(50):6618-27
Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK J. Biol. Chem. 2005 280(52):42707-14
Zhao KW, Zhao QT, Zhang SL, Miao JY Integrin beta4 mAb inhibited apoptosis induced by deprivation of growth factors in vascular endothelial cells Acta Pharmacol Sin. 2004 25(6):733-7
Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation Blood 2004 104(12):3731-8